Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient

Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated wi...

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Autores principales: Zhang, Xuewu, Wang, Jingxia, Huang, Xiaohan, Zhu, Yue, Zhu, Yijing, Tang, Lingling, Cai, Hongliu, Fang, Xueling, Huang, Lingtong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941661/
https://www.ncbi.nlm.nih.gov/pubmed/36825017
http://dx.doi.org/10.3389/fimmu.2023.1099468
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author Zhang, Xuewu
Wang, Jingxia
Huang, Xiaohan
Zhu, Yue
Zhu, Yijing
Tang, Lingling
Cai, Hongliu
Fang, Xueling
Huang, Lingtong
author_facet Zhang, Xuewu
Wang, Jingxia
Huang, Xiaohan
Zhu, Yue
Zhu, Yijing
Tang, Lingling
Cai, Hongliu
Fang, Xueling
Huang, Lingtong
author_sort Zhang, Xuewu
collection PubMed
description Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated with intravenous immune globulin (IVIG) and the features of HLH were remission. This instance emphasizes the significance of parvovirus B19 monitoring in transplant patients with anemia; if HLH complicates the situation, IVIG may be an adequate remedy. Finally, a summary of the development in diagnosing and managing parvovirus B19 infection complicated by HLH is provided.
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spelling pubmed-99416612023-02-22 Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient Zhang, Xuewu Wang, Jingxia Huang, Xiaohan Zhu, Yue Zhu, Yijing Tang, Lingling Cai, Hongliu Fang, Xueling Huang, Lingtong Front Immunol Immunology Immunosuppressed patients can contract parvovirus B19, and some may experience hemophagocytic lymphohistiocytosis (HLH). Herein, we describe the first report of hemophagocytic lymphohistiocytosis in a heart-lung transplant patient with concomitant parvovirus B19 infection. The patient was treated with intravenous immune globulin (IVIG) and the features of HLH were remission. This instance emphasizes the significance of parvovirus B19 monitoring in transplant patients with anemia; if HLH complicates the situation, IVIG may be an adequate remedy. Finally, a summary of the development in diagnosing and managing parvovirus B19 infection complicated by HLH is provided. Frontiers Media S.A. 2023-02-07 /pmc/articles/PMC9941661/ /pubmed/36825017 http://dx.doi.org/10.3389/fimmu.2023.1099468 Text en Copyright © 2023 Zhang, Wang, Huang, Zhu, Zhu, Tang, Cai, Fang and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Xuewu
Wang, Jingxia
Huang, Xiaohan
Zhu, Yue
Zhu, Yijing
Tang, Lingling
Cai, Hongliu
Fang, Xueling
Huang, Lingtong
Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
title Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
title_full Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
title_fullStr Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
title_full_unstemmed Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
title_short Case Report: Parvovirus B19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
title_sort case report: parvovirus b19 infection complicated by hemophagocytic lymphohistiocytosis in a heart-lung transplant patient
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941661/
https://www.ncbi.nlm.nih.gov/pubmed/36825017
http://dx.doi.org/10.3389/fimmu.2023.1099468
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