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Topical Delivery of ROS-Responsive Methotrexate Prodrug Nanoassemblies by a Dissolvable Microneedle Patch for Psoriasis Therapy

PURPOSE: Oxidative stress, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and adenosine signaling are factors associated with psoriatic inflammation. Topical delivery of methotrexate (MTX) has become an option to overcome the side effects caused by systemic therapy in psorias...

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Detalles Bibliográficos
Autores principales:	Zhou, Yong, Yang, Lei, Lyu, Yifu, Wu, Di, Zhu, Ying, Li, Jingjing, Jiang, Dabo, Xin, Xiaofei, Yin, Lifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941683/ https://www.ncbi.nlm.nih.gov/pubmed/36824414 http://dx.doi.org/10.2147/IJN.S394957

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