Cholestatic Liver Injury in a Patient with Tertiary Syphilis

Syphilis is a common infection that has variable presentations. We report a rare case of a 64-year-old male with 3 weeks of abdominal pain, back pain, and neurologic deficits including memory impairment who was found to have neurosyphilis causing a cholestatic liver injury. Workup included a positiv...

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Autores principales: Mujumdar, Sahaj, Goldenberg, Jason, Bieser, Steven, Pang, Alice S., Coben, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941764/
https://www.ncbi.nlm.nih.gov/pubmed/36824700
http://dx.doi.org/10.1159/000526247
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author Mujumdar, Sahaj
Goldenberg, Jason
Bieser, Steven
Pang, Alice S.
Coben, Robert
author_facet Mujumdar, Sahaj
Goldenberg, Jason
Bieser, Steven
Pang, Alice S.
Coben, Robert
author_sort Mujumdar, Sahaj
collection PubMed
description Syphilis is a common infection that has variable presentations. We report a rare case of a 64-year-old male with 3 weeks of abdominal pain, back pain, and neurologic deficits including memory impairment who was found to have neurosyphilis causing a cholestatic liver injury. Workup included a positive rapid plasma reagin (RPR) and enzyme immunoassay (EIA), a positive cerebrospinal fluid (CSF) venereal disease research laboratory (VDRL), and a liver biopsy, which was compatible with a diagnosis of syphilitic hepatitis. Completion of a 14-day course of penicillin and 1 month of physical therapy resulted in near full-functional and biochemical recovery.
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spelling pubmed-99417642023-02-22 Cholestatic Liver Injury in a Patient with Tertiary Syphilis Mujumdar, Sahaj Goldenberg, Jason Bieser, Steven Pang, Alice S. Coben, Robert Case Rep Gastroenterol Single Case Syphilis is a common infection that has variable presentations. We report a rare case of a 64-year-old male with 3 weeks of abdominal pain, back pain, and neurologic deficits including memory impairment who was found to have neurosyphilis causing a cholestatic liver injury. Workup included a positive rapid plasma reagin (RPR) and enzyme immunoassay (EIA), a positive cerebrospinal fluid (CSF) venereal disease research laboratory (VDRL), and a liver biopsy, which was compatible with a diagnosis of syphilitic hepatitis. Completion of a 14-day course of penicillin and 1 month of physical therapy resulted in near full-functional and biochemical recovery. S. Karger AG 2022-09-19 /pmc/articles/PMC9941764/ /pubmed/36824700 http://dx.doi.org/10.1159/000526247 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Mujumdar, Sahaj
Goldenberg, Jason
Bieser, Steven
Pang, Alice S.
Coben, Robert
Cholestatic Liver Injury in a Patient with Tertiary Syphilis
title Cholestatic Liver Injury in a Patient with Tertiary Syphilis
title_full Cholestatic Liver Injury in a Patient with Tertiary Syphilis
title_fullStr Cholestatic Liver Injury in a Patient with Tertiary Syphilis
title_full_unstemmed Cholestatic Liver Injury in a Patient with Tertiary Syphilis
title_short Cholestatic Liver Injury in a Patient with Tertiary Syphilis
title_sort cholestatic liver injury in a patient with tertiary syphilis
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941764/
https://www.ncbi.nlm.nih.gov/pubmed/36824700
http://dx.doi.org/10.1159/000526247
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AT pangalices cholestaticliverinjuryinapatientwithtertiarysyphilis
AT cobenrobert cholestaticliverinjuryinapatientwithtertiarysyphilis

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