Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient

A diagnosis of acute myeloid leukemia involving the central nervous system (CNS) can be confirmed through cerebrospinal fluid (CSF) and serum flow cytometry. These two detection methods should demonstrate the same immunophenotype due to hematogenous dissemination. Here, we reported a 65-year-old mal...

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Autores principales: Edirisuriya, Chelsea, Jeurkar, Chetan, Nazir, Bushra, Belovsky, Mia, Kasner, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941793/
https://www.ncbi.nlm.nih.gov/pubmed/36825101
http://dx.doi.org/10.1159/000526571
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author Edirisuriya, Chelsea
Jeurkar, Chetan
Nazir, Bushra
Belovsky, Mia
Kasner, Margaret
author_facet Edirisuriya, Chelsea
Jeurkar, Chetan
Nazir, Bushra
Belovsky, Mia
Kasner, Margaret
author_sort Edirisuriya, Chelsea
collection PubMed
description A diagnosis of acute myeloid leukemia involving the central nervous system (CNS) can be confirmed through cerebrospinal fluid (CSF) and serum flow cytometry. These two detection methods should demonstrate the same immunophenotype due to hematogenous dissemination. Here, we reported a 65-year-old male diagnosed with CNS leukemia with differing immunophenotypes between CSF and peripheral blood. This immunophenotypic shift may suggest leukemic migration within the blood-brain barrier. In addition, the case highlights the concept of leukemic heterogeneity and the importance of considering cancer heterogeneity when analyzing a tumor's genetic profile and selecting therapy for patients.
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spelling pubmed-99417932023-02-22 Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient Edirisuriya, Chelsea Jeurkar, Chetan Nazir, Bushra Belovsky, Mia Kasner, Margaret Case Rep Oncol Case Report A diagnosis of acute myeloid leukemia involving the central nervous system (CNS) can be confirmed through cerebrospinal fluid (CSF) and serum flow cytometry. These two detection methods should demonstrate the same immunophenotype due to hematogenous dissemination. Here, we reported a 65-year-old male diagnosed with CNS leukemia with differing immunophenotypes between CSF and peripheral blood. This immunophenotypic shift may suggest leukemic migration within the blood-brain barrier. In addition, the case highlights the concept of leukemic heterogeneity and the importance of considering cancer heterogeneity when analyzing a tumor's genetic profile and selecting therapy for patients. S. Karger AG 2022-10-03 /pmc/articles/PMC9941793/ /pubmed/36825101 http://dx.doi.org/10.1159/000526571 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Edirisuriya, Chelsea
Jeurkar, Chetan
Nazir, Bushra
Belovsky, Mia
Kasner, Margaret
Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient
title Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient
title_full Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient
title_fullStr Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient
title_full_unstemmed Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient
title_short Immunophenotypic Differences in Cerebrospinal Fluid and Peripheral Blood Demonstrating Cancer Heterogenicity in Acute Myeloid Leukemia Patient
title_sort immunophenotypic differences in cerebrospinal fluid and peripheral blood demonstrating cancer heterogenicity in acute myeloid leukemia patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941793/
https://www.ncbi.nlm.nih.gov/pubmed/36825101
http://dx.doi.org/10.1159/000526571
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