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Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals
Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [(15)O]H(2)O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941867/ https://www.ncbi.nlm.nih.gov/pubmed/36271598 http://dx.doi.org/10.1177/0271678X221135270 |
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author | Heeman, Fiona Visser, Denise Yaqub, Maqsood Verfaillie, Sander Timmers, Tessa Pijnenburg, Yolande AL van der Flier, Wiesje M van Berckel, Bart NM Boellaard, Ronald Lammertsma, Adriaan A Golla, Sandeep SV |
author_facet | Heeman, Fiona Visser, Denise Yaqub, Maqsood Verfaillie, Sander Timmers, Tessa Pijnenburg, Yolande AL van der Flier, Wiesje M van Berckel, Bart NM Boellaard, Ronald Lammertsma, Adriaan A Golla, Sandeep SV |
author_sort | Heeman, Fiona |
collection | PubMed |
description | Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [(15)O]H(2)O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [(15)O]H(2)O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [(15)O]H(2)O, [(18)F]florbetapir and [(18)F]flortaucipir PET test-retest (TrT) datasets with eleven, nine and fourteen subjects, respectively, were included. Analyses were performed using an arterial input model and/or a simplified reference tissue model, depending on the data available. Relative CBF values (i.e. K(1)/K(1)′ and/or R(1)) were obtained using cerebellar cortex as reference tissue and TrT repeatability (i.e. precision) was calculated and compared between tracers, parameters and clinical groups. Relative CBF had significantly better TrT repeatability than absolute CBF derived from [(15)O]H(2)O (r = −0.53), while best TrT repeatability was observed for [(18)F]florbetapir and [(18)F]flortaucipir R(1) (r = −0.23, r = −0.33). Furthermore, only R(1) showed, better TrT repeatability for cognitively normal individuals. High precision of CBF proxies could be due to a compensatory effect of the extraction fraction, although changes in extraction fraction could also bias these proxies, but not the gold standard. |
format | Online Article Text |
id | pubmed-9941867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-99418672023-02-22 Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals Heeman, Fiona Visser, Denise Yaqub, Maqsood Verfaillie, Sander Timmers, Tessa Pijnenburg, Yolande AL van der Flier, Wiesje M van Berckel, Bart NM Boellaard, Ronald Lammertsma, Adriaan A Golla, Sandeep SV J Cereb Blood Flow Metab Original Articles Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [(15)O]H(2)O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [(15)O]H(2)O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [(15)O]H(2)O, [(18)F]florbetapir and [(18)F]flortaucipir PET test-retest (TrT) datasets with eleven, nine and fourteen subjects, respectively, were included. Analyses were performed using an arterial input model and/or a simplified reference tissue model, depending on the data available. Relative CBF values (i.e. K(1)/K(1)′ and/or R(1)) were obtained using cerebellar cortex as reference tissue and TrT repeatability (i.e. precision) was calculated and compared between tracers, parameters and clinical groups. Relative CBF had significantly better TrT repeatability than absolute CBF derived from [(15)O]H(2)O (r = −0.53), while best TrT repeatability was observed for [(18)F]florbetapir and [(18)F]flortaucipir R(1) (r = −0.23, r = −0.33). Furthermore, only R(1) showed, better TrT repeatability for cognitively normal individuals. High precision of CBF proxies could be due to a compensatory effect of the extraction fraction, although changes in extraction fraction could also bias these proxies, but not the gold standard. SAGE Publications 2022-10-21 2023-03 /pmc/articles/PMC9941867/ /pubmed/36271598 http://dx.doi.org/10.1177/0271678X221135270 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Heeman, Fiona Visser, Denise Yaqub, Maqsood Verfaillie, Sander Timmers, Tessa Pijnenburg, Yolande AL van der Flier, Wiesje M van Berckel, Bart NM Boellaard, Ronald Lammertsma, Adriaan A Golla, Sandeep SV Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals |
title | Precision estimates of relative and absolute cerebral blood flow in
Alzheimer’s disease and cognitively normal individuals |
title_full | Precision estimates of relative and absolute cerebral blood flow in
Alzheimer’s disease and cognitively normal individuals |
title_fullStr | Precision estimates of relative and absolute cerebral blood flow in
Alzheimer’s disease and cognitively normal individuals |
title_full_unstemmed | Precision estimates of relative and absolute cerebral blood flow in
Alzheimer’s disease and cognitively normal individuals |
title_short | Precision estimates of relative and absolute cerebral blood flow in
Alzheimer’s disease and cognitively normal individuals |
title_sort | precision estimates of relative and absolute cerebral blood flow in
alzheimer’s disease and cognitively normal individuals |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941867/ https://www.ncbi.nlm.nih.gov/pubmed/36271598 http://dx.doi.org/10.1177/0271678X221135270 |
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