The role of (pro)renin receptor and its soluble form in cardiovascular diseases

The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a...

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Autores principales: Wang, Boyang, Jie, Haipeng, Wang, Shuangxi, Dong, Bo, Zou, Yunzeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941963/
https://www.ncbi.nlm.nih.gov/pubmed/36824459
http://dx.doi.org/10.3389/fcvm.2023.1086603
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author Wang, Boyang
Jie, Haipeng
Wang, Shuangxi
Dong, Bo
Zou, Yunzeng
author_facet Wang, Boyang
Jie, Haipeng
Wang, Shuangxi
Dong, Bo
Zou, Yunzeng
author_sort Wang, Boyang
collection PubMed
description The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a new member of RAS in 2002. Studies have demonstrated the effects of PRR and its soluble form in local tissue RAS. Moreover, as an important part of vacuolar H(+)-ATPase, it also contributes to normal lysosome function and cell survival. Evidently, PRR participates in the pathogenesis of cardiovascular diseases and may be a potential therapeutic target of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on the physiological state, hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis. We aimed to investigate the possibilities and challenges of PRR and its soluble form as a new therapeutic target in cardiovascular diseases.
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spelling pubmed-99419632023-02-22 The role of (pro)renin receptor and its soluble form in cardiovascular diseases Wang, Boyang Jie, Haipeng Wang, Shuangxi Dong, Bo Zou, Yunzeng Front Cardiovasc Med Cardiovascular Medicine The renin-angiotensin system (RAS) is a major classic therapeutic target for cardiovascular diseases. In addition to the circulating RAS, local tissue RAS has been identified in various tissues and plays roles in tissue inflammation and tissue fibrosis. (Pro)renin receptor (PRR) was identified as a new member of RAS in 2002. Studies have demonstrated the effects of PRR and its soluble form in local tissue RAS. Moreover, as an important part of vacuolar H(+)-ATPase, it also contributes to normal lysosome function and cell survival. Evidently, PRR participates in the pathogenesis of cardiovascular diseases and may be a potential therapeutic target of cardiovascular diseases. This review focuses on the effects of PRR and its soluble form on the physiological state, hypertension, myocardial ischemia reperfusion injury, heart failure, metabolic cardiomyopathy, and atherosclerosis. We aimed to investigate the possibilities and challenges of PRR and its soluble form as a new therapeutic target in cardiovascular diseases. Frontiers Media S.A. 2023-02-02 /pmc/articles/PMC9941963/ /pubmed/36824459 http://dx.doi.org/10.3389/fcvm.2023.1086603 Text en Copyright © 2023 Wang, Jie, Wang, Dong and Zou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wang, Boyang
Jie, Haipeng
Wang, Shuangxi
Dong, Bo
Zou, Yunzeng
The role of (pro)renin receptor and its soluble form in cardiovascular diseases
title The role of (pro)renin receptor and its soluble form in cardiovascular diseases
title_full The role of (pro)renin receptor and its soluble form in cardiovascular diseases
title_fullStr The role of (pro)renin receptor and its soluble form in cardiovascular diseases
title_full_unstemmed The role of (pro)renin receptor and its soluble form in cardiovascular diseases
title_short The role of (pro)renin receptor and its soluble form in cardiovascular diseases
title_sort role of (pro)renin receptor and its soluble form in cardiovascular diseases
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941963/
https://www.ncbi.nlm.nih.gov/pubmed/36824459
http://dx.doi.org/10.3389/fcvm.2023.1086603
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