Cargando…

Discovery of All-d-Peptide Inhibitors of SARS-CoV-2 3C-like Protease

[Image: see text] During the replication process of SARS-CoV-2, the main protease of the virus [3-chymotrypsin-like protease (3CL(pro))] plays a pivotal role and is essential for the life cycle of the pathogen. Numerous studies have been conducted so far, which have confirmed 3CL(pro) as an attracti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eberle, Raphael J., Sevenich, Marc, Gering, Ian, Scharbert, Lara, Strodel, Birgit, Lakomek, Nils A., Santur, Karoline, Mohrlüder, Jeannine, Coronado, Mônika A., Willbold, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942092/ https://www.ncbi.nlm.nih.gov/pubmed/36647580 http://dx.doi.org/10.1021/acschembio.2c00735

Ejemplares similares

A So-Far Overlooked Secondary Conformation State in the Binding Mode of SARS-CoV-2 Spike Protein to Human ACE2 and Its Conversion Rate Are Crucial for Estimating Infectivity Efficacy of the Underlying Virus Variant
por: Sevenich, Marc, et al.
Publicado: (2022)

A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main Protease
por: Hernández González, Jorge E., et al.
Publicado: (2022)

The Importance of Epigallocatechin as a Scaffold for Drug Development against Flaviviruses
por: Coronado, Mônika A., et al.
Publicado: (2023)

Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein
por: Sevenich, Marc, et al.
Publicado: (2022)

Tau protein aggregation associated with SARS-CoV-2 main protease
por: Eberle, Raphael Josef, et al.
Publicado: (2023)

Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer’s Disease and Other Tauopathies
por: Altendorf, Tim, et al.
Publicado: (2023)

Inhibition of Polyglutamine Misfolding with D-Enantiomeric Peptides Identified by Mirror Image Phage Display Selection
por: Kolkwitz, Pauline Elisabeth, et al.
Publicado: (2022)

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold
por: Eberle, Raphael J., et al.
Publicado: (2022)

The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CL(pro) In Vitro
por: Eberle, Raphael J., et al.
Publicado: (2021)

Promising Natural Compounds against Flavivirus Proteases: Citrus Flavonoids Hesperetin and Hesperidin
por: Eberle, Raphael J., et al.
Publicado: (2021)

Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay
por: Loschwitz, Jennifer, et al.
Publicado: (2021)

Riboflavin, a Potent Neuroprotective Vitamin: Focus on Flavivirus and Alphavirus Proteases
por: Eberle, Raphael J., et al.
Publicado: (2022)

In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases
por: Eberle, Raphael J., et al.
Publicado: (2021)

In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer’s Disease
por: Schemmert, Sarah, et al.
Publicado: (2021)

Interference with Amyloid-β Nucleation by Transient Ligand Interaction
por: Zhang, Tao, et al.
Publicado: (2019)

The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels
por: Simons, Indra M., et al.
Publicado: (2019)

Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels
por: Simons, Indra M., et al.
Publicado: (2019)

High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2
por: Olubiyi, Olujide O., et al.
Publicado: (2020)

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease
por: Schartmann, Elena, et al.
Publicado: (2018)

Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo
por: Braczynski, Anne K., et al.
Publicado: (2022)

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site
por: Krichel, Carsten, et al.
Publicado: (2019)

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses
por: Cukkemane, Abhishek, et al.
Publicado: (2021)

Does the inclusion of electronic polarisability lead to a better modelling of peptide aggregation?
por: Kav, Batuhan, et al.
Publicado: (2022)

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution
por: Wolff, Martin, et al.
Publicado: (2017)

Stability of Transmembrane Amyloid β-Peptide and Membrane Integrity Tested by Molecular Modeling of Site-Specific Aβ (42) Mutations
por: Poojari, Chetan, et al.
Publicado: (2013)

Early Diagnosis and Classification of Fetal Health Status from a Fetal Cardiotocography Dataset Using Ensemble Learning
por: Kuzu, Adem, et al.
Publicado: (2023)

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
por: Viennet, Thibault, et al.
Publicado: (2018)

A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus
por: Peinado, Rafaela dos S., et al.
Publicado: (2022)

Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease
por: Olubiyi, Olujide O., et al.
Publicado: (2019)

Peptides for Therapy and Diagnosis of Alzheimer’s Disease
por: Funke, Susanne Aileen, et al.
Publicado: (2012)

Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion
por: Lakomek, Nils-Alexander, et al.
Publicado: (2019)

Structure and Dynamics of Human Chemokine CCL16—Implications for Biological Activity
por: Weiergräber, Oliver H., et al.
Publicado: (2022)

Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1(G93A) Transgenic Mice
por: Post, Julia, et al.
Publicado: (2021)

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers
por: Elfgen, Anne, et al.
Publicado: (2019)

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination
por: Klein, Antonia Nicole, et al.
Publicado: (2016)

Thermodynamics and kinetics of the amyloid-β peptide revealed by Markov state models based on MD data in agreement with experiment
por: Paul, Arghadwip, et al.
Publicado: (2021)

Topology and parameter data of thirteen non-natural amino acids for molecular simulations with CHARMM22
por: Olubiyi, Olujide O., et al.
Publicado: (2016)

Evaluation of the coarse-grained OPEP force field for protein-protein docking
por: Kynast, Philipp, et al.
Publicado: (2016)

Large-scale, dynamin-like motions of the human guanylate binding protein 1 revealed by multi-resolution simulations
por: Barz, Bogdan, et al.
Publicado: (2019)

Transition Networks Unveil Disorder-to-Order Transformations in Aβ Caused by Glycosaminoglycans or Lipids
por: Schäffler, Moritz, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_emhmm83ta8otecboi18nj2m4c4