Global profiling of AMG510 modified proteins identified tumor suppressor KEAP1 as an off-target

KRAS inhibitor AMG510 covalently modifies the G12C residue and inactivates the KRAS/G12C function. Because there are many reactive cysteines in the proteome, it is important to characterize AMG510 on-target modification and off-targets. Here, we presented a streamlined workflow to measure abundant A...

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Detalles Bibliográficos
Autores principales: Wang, Yini, Zhong, Bowen, Xu, Caixia, Zhan, Dongdong, Zhao, Songhao, Wu, Hongxing, Liu, Mingwei, Lan, Xiaoling, Cai, Danni, Ding, Qian, Zheng, Biao, Lan, Jiong, Lv, Qiang, Wang, Yi, Qin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942120/
https://www.ncbi.nlm.nih.gov/pubmed/36824285
http://dx.doi.org/10.1016/j.isci.2023.106080

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