Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy

In the absence of targetable hormonal axes, chemoresistance for triple-negative breast cancer (TNBC) often compromises patient outcomes. To investigate the underlying tumor dynamics, we performed trajectory analysis on the single-nuclei RNA-seq (snRNA-seq) of chemoresistant tumor clones during neoad...

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Detalles Bibliográficos
Autores principales: Song, Won-Min, Chia, Pei-Ling, Zhou, Xianxiao, Walsh, Martin, Silva, Jose, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942122/
https://www.ncbi.nlm.nih.gov/pubmed/36824282
http://dx.doi.org/10.1016/j.isci.2023.106064

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