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Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection
BACKGROUND: Despite the increasing application of tolvaptan in cardiac surgery, there is no information on the use of tolvaptan in Stanford patients with type A aortic dissection. This study aimed to evaluate the postoperative clinical effects of tolvaptan in patients with type A aortic dissection ...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942290/ https://www.ncbi.nlm.nih.gov/pubmed/36803437 http://dx.doi.org/10.1186/s12872-023-03125-x |
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author | Wang, Wenjun Gao, Feng He, Xuezhi Gao, Yang Shi, Lei Liu, Wei Zhuang, Xijing |
author_facet | Wang, Wenjun Gao, Feng He, Xuezhi Gao, Yang Shi, Lei Liu, Wei Zhuang, Xijing |
author_sort | Wang, Wenjun |
collection | PubMed |
description | BACKGROUND: Despite the increasing application of tolvaptan in cardiac surgery, there is no information on the use of tolvaptan in Stanford patients with type A aortic dissection. This study aimed to evaluate the postoperative clinical effects of tolvaptan in patients with type A aortic dissection after tafter surgery. METHODS: A retrospective analysis was performed on 45 patients treated for type A aortic dissection in our hospital from 2018 to 2020. These included 21 patients who were treated with tolvaptan (Group T) and 24 patients who received traditional diuretics (Group L). The hospital's electronic health records were used to obtain perioperative data. RESULTS: Group T did not differ significantly from Group L in terms of the duration of mechanical ventilation, postoperative blood required, length of catecholamine use, or the amount of intravenous diuretic drugs administered (all P > 0.05). The development of postoperative atrial fibrillation was significantly less in the tolvaptan group (P = 0.023). The urine volumes and change in body weight loss were slightly higher in group T than in group L but the differences were non-significant (P > 0.05). Serum potassium, creatinine, and urea nitrogen levels did not differ between the groups in the week after surgery, At the same time, sodium was significantly higher in the Group T group on day 7 after transfer from the ICU (P = 0.001). In Group L, sodium levels were also elevated by day 7 (P = 0.001). On days 3 and 7, serum creatinine and urea nitrogen levels increased in both groups (both P < 0.05). CONCLUSIONS: Both tolvaptan and traditional diuretics were found to be effective and safe for patients with acute Stanford type A aortic dissection. Moreover, tolvaptan may be associated with reducing the incidence of postoperative atrial fibrillation. |
format | Online Article Text |
id | pubmed-9942290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99422902023-02-22 Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection Wang, Wenjun Gao, Feng He, Xuezhi Gao, Yang Shi, Lei Liu, Wei Zhuang, Xijing BMC Cardiovasc Disord Research BACKGROUND: Despite the increasing application of tolvaptan in cardiac surgery, there is no information on the use of tolvaptan in Stanford patients with type A aortic dissection. This study aimed to evaluate the postoperative clinical effects of tolvaptan in patients with type A aortic dissection after tafter surgery. METHODS: A retrospective analysis was performed on 45 patients treated for type A aortic dissection in our hospital from 2018 to 2020. These included 21 patients who were treated with tolvaptan (Group T) and 24 patients who received traditional diuretics (Group L). The hospital's electronic health records were used to obtain perioperative data. RESULTS: Group T did not differ significantly from Group L in terms of the duration of mechanical ventilation, postoperative blood required, length of catecholamine use, or the amount of intravenous diuretic drugs administered (all P > 0.05). The development of postoperative atrial fibrillation was significantly less in the tolvaptan group (P = 0.023). The urine volumes and change in body weight loss were slightly higher in group T than in group L but the differences were non-significant (P > 0.05). Serum potassium, creatinine, and urea nitrogen levels did not differ between the groups in the week after surgery, At the same time, sodium was significantly higher in the Group T group on day 7 after transfer from the ICU (P = 0.001). In Group L, sodium levels were also elevated by day 7 (P = 0.001). On days 3 and 7, serum creatinine and urea nitrogen levels increased in both groups (both P < 0.05). CONCLUSIONS: Both tolvaptan and traditional diuretics were found to be effective and safe for patients with acute Stanford type A aortic dissection. Moreover, tolvaptan may be associated with reducing the incidence of postoperative atrial fibrillation. BioMed Central 2023-02-21 /pmc/articles/PMC9942290/ /pubmed/36803437 http://dx.doi.org/10.1186/s12872-023-03125-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Wang, Wenjun Gao, Feng He, Xuezhi Gao, Yang Shi, Lei Liu, Wei Zhuang, Xijing Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection |
title | Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection |
title_full | Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection |
title_fullStr | Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection |
title_full_unstemmed | Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection |
title_short | Efficacy of tolvaptan in postoperative volume therapy for acute Stanford type A aortic dissection |
title_sort | efficacy of tolvaptan in postoperative volume therapy for acute stanford type a aortic dissection |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942290/ https://www.ncbi.nlm.nih.gov/pubmed/36803437 http://dx.doi.org/10.1186/s12872-023-03125-x |
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