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Transcriptomic intratumor heterogeneity of breast cancer patient-derived organoids may reflect the unique biological features of the tumor of origin

BACKGROUND: The intratumor heterogeneity (ITH) of cancer cells plays an important role in breast cancer resistance and recurrence. To develop better therapeutic strategies, it is necessary to understand the molecular mechanisms underlying ITH and their functional significance. Patient-derived organo...

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Detalles Bibliográficos
Autores principales:	Saeki, Sumito, Kumegawa, Kohei, Takahashi, Yoko, Yang, Liying, Osako, Tomo, Yasen, Mahmut, Otsuji, Kazutaka, Miyata, Kenichi, Yamakawa, Kaoru, Suzuka, Jun, Sakimoto, Yuri, Ozaki, Yukinori, Takano, Toshimi, Sano, Takeshi, Noda, Tetsuo, Ohno, Shinji, Yao, Ryoji, Ueno, Takayuki, Maruyama, Reo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942352/ https://www.ncbi.nlm.nih.gov/pubmed/36810117 http://dx.doi.org/10.1186/s13058-023-01617-4

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