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Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes

BACKGROUND: We used magnetic resonance imaging (MRI) to study kidney energetics in persons with and without type 1 diabetes (T1D). METHODS: In a cross-sectional study, 15 persons with T1D and albuminuria and 15 non-diabetic controls (CONs) underwent multiparametric MRI (3 Tesla Philips Scanner) to q...

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Autores principales: Laursen, Jens Christian, Søndergaard-Heinrich, Niels, Haddock, Bryan, Rasmussen, Ida Kirstine Bull, Hansen, Christian Stevns, Larsson, Henrik Bo Wiberg, Groop, Per-Henrik, Bjornstad, Petter, Frimodt-Møller, Marie, Andersen, Ulrik Bjørn, Rossing, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942445/
https://www.ncbi.nlm.nih.gov/pubmed/36825032
http://dx.doi.org/10.1093/ckj/sfac145
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author Laursen, Jens Christian
Søndergaard-Heinrich, Niels
Haddock, Bryan
Rasmussen, Ida Kirstine Bull
Hansen, Christian Stevns
Larsson, Henrik Bo Wiberg
Groop, Per-Henrik
Bjornstad, Petter
Frimodt-Møller, Marie
Andersen, Ulrik Bjørn
Rossing, Peter
author_facet Laursen, Jens Christian
Søndergaard-Heinrich, Niels
Haddock, Bryan
Rasmussen, Ida Kirstine Bull
Hansen, Christian Stevns
Larsson, Henrik Bo Wiberg
Groop, Per-Henrik
Bjornstad, Petter
Frimodt-Møller, Marie
Andersen, Ulrik Bjørn
Rossing, Peter
author_sort Laursen, Jens Christian
collection PubMed
description BACKGROUND: We used magnetic resonance imaging (MRI) to study kidney energetics in persons with and without type 1 diabetes (T1D). METHODS: In a cross-sectional study, 15 persons with T1D and albuminuria and 15 non-diabetic controls (CONs) underwent multiparametric MRI (3 Tesla Philips Scanner) to quantify renal cortical and medullary oxygenation (R(2)*, higher values correspond to higher deoxyhaemoglobin concentration), renal perfusion (arterial spin labelling) and renal artery blood flow (phase contrast). Analyses were adjusted for age, sex, systolic blood pressure, plasma haemoglobin, body mass index and estimated glomerular filtration rate (eGFR). RESULTS: Participants with T1D had a higher median (Q1; Q3) urine albumin creatinine ratio (UACR) than CONs [46 (21; 58) versus 4 (3; 6) mg/g; P < .0001] and a lower mean ± SD eGFR (73 ± 32 mL/min/1.73 m(2) versus 88 ± 15 mL/min/1.73 m(2);  P = .12), although not significantly. Mean medullary R(2)* was lower in T1D (34 ± 6/s versus 38 ± 5/s; P < .01) corresponding to a higher oxygenation. R(2)* was not different in the cortex. Cortical perfusion was lower in T1D (163 ± 40 versus 224 ± 49 mL/100 g/min; P < .001). Renal artery blood flow was lower in T1D than in CONs (360 ± 130 versus 430 ± 113 mL/min; P = .05). In T1D, lower cortical oxygenation and renal artery blood flow were both associated with higher UACR and lower eGFR (P < .05). CONCLUSIONS: Participants with T1D and albuminuria exhibited higher medullary oxygenation than CONs, despite lower cortical perfusion and renal artery blood flow. This might reflect perturbed kidney energetics leading to a higher setpoint of medullary oxygenation in T1D. Lower cortical oxygenation and renal artery blood flow were associated with higher UACR and lower eGFR in T1D.
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spelling pubmed-99424452023-02-22 Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes Laursen, Jens Christian Søndergaard-Heinrich, Niels Haddock, Bryan Rasmussen, Ida Kirstine Bull Hansen, Christian Stevns Larsson, Henrik Bo Wiberg Groop, Per-Henrik Bjornstad, Petter Frimodt-Møller, Marie Andersen, Ulrik Bjørn Rossing, Peter Clin Kidney J Original Article BACKGROUND: We used magnetic resonance imaging (MRI) to study kidney energetics in persons with and without type 1 diabetes (T1D). METHODS: In a cross-sectional study, 15 persons with T1D and albuminuria and 15 non-diabetic controls (CONs) underwent multiparametric MRI (3 Tesla Philips Scanner) to quantify renal cortical and medullary oxygenation (R(2)*, higher values correspond to higher deoxyhaemoglobin concentration), renal perfusion (arterial spin labelling) and renal artery blood flow (phase contrast). Analyses were adjusted for age, sex, systolic blood pressure, plasma haemoglobin, body mass index and estimated glomerular filtration rate (eGFR). RESULTS: Participants with T1D had a higher median (Q1; Q3) urine albumin creatinine ratio (UACR) than CONs [46 (21; 58) versus 4 (3; 6) mg/g; P < .0001] and a lower mean ± SD eGFR (73 ± 32 mL/min/1.73 m(2) versus 88 ± 15 mL/min/1.73 m(2);  P = .12), although not significantly. Mean medullary R(2)* was lower in T1D (34 ± 6/s versus 38 ± 5/s; P < .01) corresponding to a higher oxygenation. R(2)* was not different in the cortex. Cortical perfusion was lower in T1D (163 ± 40 versus 224 ± 49 mL/100 g/min; P < .001). Renal artery blood flow was lower in T1D than in CONs (360 ± 130 versus 430 ± 113 mL/min; P = .05). In T1D, lower cortical oxygenation and renal artery blood flow were both associated with higher UACR and lower eGFR (P < .05). CONCLUSIONS: Participants with T1D and albuminuria exhibited higher medullary oxygenation than CONs, despite lower cortical perfusion and renal artery blood flow. This might reflect perturbed kidney energetics leading to a higher setpoint of medullary oxygenation in T1D. Lower cortical oxygenation and renal artery blood flow were associated with higher UACR and lower eGFR in T1D. Oxford University Press 2022-05-20 /pmc/articles/PMC9942445/ /pubmed/36825032 http://dx.doi.org/10.1093/ckj/sfac145 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Laursen, Jens Christian
Søndergaard-Heinrich, Niels
Haddock, Bryan
Rasmussen, Ida Kirstine Bull
Hansen, Christian Stevns
Larsson, Henrik Bo Wiberg
Groop, Per-Henrik
Bjornstad, Petter
Frimodt-Møller, Marie
Andersen, Ulrik Bjørn
Rossing, Peter
Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
title Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
title_full Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
title_fullStr Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
title_full_unstemmed Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
title_short Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
title_sort kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942445/
https://www.ncbi.nlm.nih.gov/pubmed/36825032
http://dx.doi.org/10.1093/ckj/sfac145
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