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Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient
Patient: Female, 73-year-old Final Diagnosis: Hamartoma • iron deficiency anemia Symptoms: Fatigue Clinical Procedure: Endoscopy Specialty: Gastroenterology and Hepatology OBJECTIVE: Rare disease BACKGROUND: Hamartomatous polyps represent rare sporadic lesions, characterized by fibrous stroma, vascu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942536/ https://www.ncbi.nlm.nih.gov/pubmed/36798003 http://dx.doi.org/10.12659/AJCR.938929 |
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author | Mahmoud, Anas Soliman, Isaac M. Kania, Brooke E. Ghrewati, Moutaz Baddoura, Walid |
author_facet | Mahmoud, Anas Soliman, Isaac M. Kania, Brooke E. Ghrewati, Moutaz Baddoura, Walid |
author_sort | Mahmoud, Anas |
collection | PubMed |
description | Patient: Female, 73-year-old Final Diagnosis: Hamartoma • iron deficiency anemia Symptoms: Fatigue Clinical Procedure: Endoscopy Specialty: Gastroenterology and Hepatology OBJECTIVE: Rare disease BACKGROUND: Hamartomatous polyps represent rare sporadic lesions, characterized by fibrous stroma, vascular infiltration, and dilation of mucous glands. The lesions present in a bimodal fashion in adults as well as children from 1 to 7 years old, and are often diagnosed during endoscopic procedures. Specifically, solitary Peutz-Jeghers represents a type of hamartoma that has similar histologic features to typical Peutz-Jeghers syndrome. Hamartomatous polyps represent disorganized tissue growth and can bear relationships with genetic syndromes classified as hamartomatous polyposis syndromes. A number of these syndromes, such as Peutz-Jeghers and Cowden syndrome, can demonstrate an increased risk of malignancy. A variety of symptoms, or no symptoms at all, can accompany these polyps, such as abdominal discomfort, bowel obstruction, gastrointestinal bleeding, or intussusception in severe cases. Histologically, these polyps appear similar to Peutz-Jeghers syndrome growths; however, they lack extraintestinal manifestations. Given fairly low risk of development into malignancy, patients have a good prognosis if presenting with a solitary hamartomatous polyp. There is limited data regarding screening guidelines for this patient population. CASE REPORT: Here, we present a rare case of a 73-year-old woman who had a history of anemia and status post endoscopic evaluation and was diagnosed with a benign hamartomatous polyp (juvenile-like), histologically consistent with tubulovillous adenoma. CONCLUSIONS: Differentiating sporadic polyps from syndromic polyps is important, as sporadic polyps have a benign course, while those associated with a syndrome have an increased lifetime malignancy risk. |
format | Online Article Text |
id | pubmed-9942536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99425362023-02-22 Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient Mahmoud, Anas Soliman, Isaac M. Kania, Brooke E. Ghrewati, Moutaz Baddoura, Walid Am J Case Rep Articles Patient: Female, 73-year-old Final Diagnosis: Hamartoma • iron deficiency anemia Symptoms: Fatigue Clinical Procedure: Endoscopy Specialty: Gastroenterology and Hepatology OBJECTIVE: Rare disease BACKGROUND: Hamartomatous polyps represent rare sporadic lesions, characterized by fibrous stroma, vascular infiltration, and dilation of mucous glands. The lesions present in a bimodal fashion in adults as well as children from 1 to 7 years old, and are often diagnosed during endoscopic procedures. Specifically, solitary Peutz-Jeghers represents a type of hamartoma that has similar histologic features to typical Peutz-Jeghers syndrome. Hamartomatous polyps represent disorganized tissue growth and can bear relationships with genetic syndromes classified as hamartomatous polyposis syndromes. A number of these syndromes, such as Peutz-Jeghers and Cowden syndrome, can demonstrate an increased risk of malignancy. A variety of symptoms, or no symptoms at all, can accompany these polyps, such as abdominal discomfort, bowel obstruction, gastrointestinal bleeding, or intussusception in severe cases. Histologically, these polyps appear similar to Peutz-Jeghers syndrome growths; however, they lack extraintestinal manifestations. Given fairly low risk of development into malignancy, patients have a good prognosis if presenting with a solitary hamartomatous polyp. There is limited data regarding screening guidelines for this patient population. CASE REPORT: Here, we present a rare case of a 73-year-old woman who had a history of anemia and status post endoscopic evaluation and was diagnosed with a benign hamartomatous polyp (juvenile-like), histologically consistent with tubulovillous adenoma. CONCLUSIONS: Differentiating sporadic polyps from syndromic polyps is important, as sporadic polyps have a benign course, while those associated with a syndrome have an increased lifetime malignancy risk. International Scientific Literature, Inc. 2023-02-17 /pmc/articles/PMC9942536/ /pubmed/36798003 http://dx.doi.org/10.12659/AJCR.938929 Text en © Am J Case Rep, 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Mahmoud, Anas Soliman, Isaac M. Kania, Brooke E. Ghrewati, Moutaz Baddoura, Walid Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient |
title | Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient |
title_full | Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient |
title_fullStr | Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient |
title_full_unstemmed | Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient |
title_short | Rare Isolated Duodenal Hamartomatous Polyp in an Elderly Patient |
title_sort | rare isolated duodenal hamartomatous polyp in an elderly patient |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942536/ https://www.ncbi.nlm.nih.gov/pubmed/36798003 http://dx.doi.org/10.12659/AJCR.938929 |
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