Cargando…

Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis

Sepsis, a heterogeneous clinical syndrome, features a systemic inflammatory response to tissue injury or infection, followed by a state of reduced immune responsiveness. Measurable alterations occur in both the innate and adaptive immune systems. Immunoparalysis, an immunosuppressed state, associate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Joshi, Ila, Carney, Walter P., Rock, Edwin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942705/ https://www.ncbi.nlm.nih.gov/pubmed/36825018 http://dx.doi.org/10.3389/fimmu.2023.1130214

Ejemplares similares

Clarithromycin reverses sepsis-induced immunoparalysis of monocytes
por: Raftogiannis, M, et al.
Publicado: (2009)

Interferon-gamma reverses sepsis-induced immunoparalysis of monocytes in vitro
por: Mouktaroudi, M, et al.
Publicado: (2010)

Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells
por: Weisheit, Christina K., et al.
Publicado: (2020)

HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
por: Perry, Sara E, et al.
Publicado: (2004)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

CD4 T Cell Responses and the Sepsis-Induced Immunoparalysis State
por: Martin, Matthew D., et al.
Publicado: (2020)

Long-Term Follow-Up of Sepsis Induced Immunoparalysis
por: Raja, M, et al.
Publicado: (2015)

Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
por: Fan, Xia, et al.
Publicado: (2015)

HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis
por: Quirant-Sánchez, Bibiana, et al.
Publicado: (2023)

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies
por: Bonaventura, Aldo, et al.
Publicado: (2020)

Coronary artery bypass grafting is associated with immunoparalysis of monocytes and dendritic cells
por: Perros, Alexis J., et al.
Publicado: (2020)

Effect of interferon gamma on sepsis-related death in patients with immunoparalysis
por: Takeyama, N, et al.
Publicado: (2004)

Functional characterization of GM-CSF induced monocyte subsets
por: Däbritz, J, et al.
Publicado: (2008)

A Review of GM-CSF Therapy in Sepsis
por: Mathias, Brittany, et al.
Publicado: (2015)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment
por: Bosteels, Cedric, et al.
Publicado: (2022)

Monocyte HLA-DR in sepsis: shall we stop following the flow?
por: Monneret, Guillaume, et al.
Publicado: (2014)

GM-CSF Primes Proinflammatory Monocyte Responses in Ankylosing Spondylitis
por: Shi, Hui, et al.
Publicado: (2020)

Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury
por: Wu, Huang-Pin, et al.
Publicado: (2022)

MicroRNAs 143 and 150 in whole blood enable detection of T-cell immunoparalysis in sepsis
por: Möhnle, P, et al.
Publicado: (2018)

Mitochondrial DNA mediates immunoparalysis of dendritic cells in sepsis via STING signalling
por: Tu, Qing, et al.
Publicado: (2022)

Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes
por: Lotfi, Noushin, et al.
Publicado: (2020)

Comparison of neutrophil CD64 and monocytic HLA-DR with existing biomarkers for the diagnosis and prognosis of sepsis
por: Pandey, Kshitij, et al.
Publicado: (2021)

Expression of mRNA levels of HLA-DRA in relation to monocyte HLA-DR: a longitudinal sepsis study
por: Cajander, SC, et al.
Publicado: (2015)

Bacterial load plays a crucial role for survival in experimental peritonitis and modulates immunoparalysis of monocytes
por: Atmatzidis, S, et al.
Publicado: (2010)

HLA-DR expression on monocytes is decreased in polytraumatized patients
por: Vester, Helen, et al.
Publicado: (2015)

Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells
por: Schrijver, David P., et al.
Publicado: (2023)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

Early Immunoparalysis Was Associated with Poor Prognosis in Elderly Patients with Sepsis: Secondary Analysis of the ETASS Study
por: Pei, Fei, et al.
Publicado: (2020)

Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis
por: Bline, Katherine E., et al.
Publicado: (2020)

Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses
por: Sjaastad, Frances V., et al.
Publicado: (2018)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

GM-CSF Monocyte-Derived Cells and Langerhans Cells As Part of the Dendritic Cell Family
por: Lutz, Manfred B., et al.
Publicado: (2017)

Immunoparalysis in patients with acute respiratory distress syndrome
por: Lahana, A, et al.
Publicado: (2008)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

Advancing our understanding of monocyte HLA-DR, S100A9, and the potential for individualized therapies in sepsis
por: Monneret, Guillaume
Publicado: (2023)

Utility of Monocyte Expression of HLA-DR versus T Lymphocyte Frequency in the Assessment of COVID-19 Outcome
por: Hammad, Reham, et al.
Publicado: (2022)

The efficacy and safety of targeting GM-CSF in arthritis
por: Bykerk, Vivian P
Publicado: (2020)

279. Inhaled Sargramostim (rhu GM-CSF) Leads to Enhanced SARS-CoV-2 Virus-Specific Immune Response and Viral Clearance: Results of the Biomarker Cohort of a Randomized, Double-Blind, Placebo-Controlled Phase 2b Trial in Non-Hospitalized Patients with COVID-19
por: Joshi, Ila, et al.
Publicado: (2023)

Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis
por: Snyder, Andrew, et al.
Publicado: (2021)

Skeletal Muscle and Lymphocyte Mitochondrial Dysfunctions in Septic Shock Trigger ICU-Acquired Weakness and Sepsis-Induced Immunoparalysis
por: Maestraggi, Quentin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_luk2gpg62503tirrf8mt7t16ga