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What predicts better prognosis in elderly breast cancer patients?

PURPOSE: As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes. METHODS: In t...

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Autores principales: Jung, Youn Joo, Lee, Seungju, Kim, Hyun Yul, Paik, Hyun-June, Jung, Chang Shin, Kim, Jee Yeon, Jung, Hyuk Jae, Lee, Seokwon, Kim, Choongrak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Surgical Oncology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942720/
https://www.ncbi.nlm.nih.gov/pubmed/36945300
http://dx.doi.org/10.14216/kjco.20009
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author Jung, Youn Joo
Lee, Seungju
Kim, Hyun Yul
Paik, Hyun-June
Jung, Chang Shin
Kim, Jee Yeon
Jung, Hyuk Jae
Lee, Seokwon
Kim, Choongrak
author_facet Jung, Youn Joo
Lee, Seungju
Kim, Hyun Yul
Paik, Hyun-June
Jung, Chang Shin
Kim, Jee Yeon
Jung, Hyuk Jae
Lee, Seokwon
Kim, Choongrak
author_sort Jung, Youn Joo
collection PubMed
description PURPOSE: As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes. METHODS: In this retrospective study, the data of 286 breast cancer patients aged 65 years and older, who underwent treatment at the Pusan National University Hospital and Pusan National University Yangsan Hospital from 2008 to 2014, were analyzed. The patients were divided into two groups: those with recurrence or metastasis and those without. Cox-regression model was used to analyze the risk factors for recurrence or metastasis. Kaplan-Meier method was used to analyze survival rates by the log-rank test. RESULTS: Among the 286 patients with invasive breast cancer, 43 patients (15.0%) had recurrence or distant metastasis during a median follow-up period of 61 months. Advanced stages of breast cancer and patients who are not adapted to endocrine therapy were associated with poor prognosis. CONCLUSION: In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an earlier stage, which can lead to a better prognosis. Moreover, endocrine therapy should be administered to elderly patients who manifest favorable intrinsic subtypes of breast cancer.
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spelling pubmed-99427202023-03-20 What predicts better prognosis in elderly breast cancer patients? Jung, Youn Joo Lee, Seungju Kim, Hyun Yul Paik, Hyun-June Jung, Chang Shin Kim, Jee Yeon Jung, Hyuk Jae Lee, Seokwon Kim, Choongrak Korean J Clin Oncol Original Article PURPOSE: As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes. METHODS: In this retrospective study, the data of 286 breast cancer patients aged 65 years and older, who underwent treatment at the Pusan National University Hospital and Pusan National University Yangsan Hospital from 2008 to 2014, were analyzed. The patients were divided into two groups: those with recurrence or metastasis and those without. Cox-regression model was used to analyze the risk factors for recurrence or metastasis. Kaplan-Meier method was used to analyze survival rates by the log-rank test. RESULTS: Among the 286 patients with invasive breast cancer, 43 patients (15.0%) had recurrence or distant metastasis during a median follow-up period of 61 months. Advanced stages of breast cancer and patients who are not adapted to endocrine therapy were associated with poor prognosis. CONCLUSION: In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an earlier stage, which can lead to a better prognosis. Moreover, endocrine therapy should be administered to elderly patients who manifest favorable intrinsic subtypes of breast cancer. Korean Society of Surgical Oncology 2020-06 2020-06-30 /pmc/articles/PMC9942720/ /pubmed/36945300 http://dx.doi.org/10.14216/kjco.20009 Text en Copyright © Korean Society of Surgical Oncology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Youn Joo
Lee, Seungju
Kim, Hyun Yul
Paik, Hyun-June
Jung, Chang Shin
Kim, Jee Yeon
Jung, Hyuk Jae
Lee, Seokwon
Kim, Choongrak
What predicts better prognosis in elderly breast cancer patients?
title What predicts better prognosis in elderly breast cancer patients?
title_full What predicts better prognosis in elderly breast cancer patients?
title_fullStr What predicts better prognosis in elderly breast cancer patients?
title_full_unstemmed What predicts better prognosis in elderly breast cancer patients?
title_short What predicts better prognosis in elderly breast cancer patients?
title_sort what predicts better prognosis in elderly breast cancer patients?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942720/
https://www.ncbi.nlm.nih.gov/pubmed/36945300
http://dx.doi.org/10.14216/kjco.20009
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