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Risk of osteoporosis and fracture in long-term breast cancer survivors

PURPOSE: High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought to determine whether long-term breast cancer survivors had an elevated risk of low bone dens...

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Detalles Bibliográficos
Autores principales: Go, Jieon, Park, Suyeon, Kim, Kyeong Sik, Kang, Min Chang, Ihn, Myong Hoon, Yun, Sangchul, Kim, Sang Hyun, Hong, Sung Hoon, Lee, Jong Eun, Han, Sun Wook, Kim, Sung Yong, Kim, Zisun, Hur, Sung Mo, Lee, Jihyoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Surgical Oncology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942721/
https://www.ncbi.nlm.nih.gov/pubmed/36945309
http://dx.doi.org/10.14216/kjco.20007
Descripción
Sumario:PURPOSE: High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought to determine whether long-term breast cancer survivors had an elevated risk of low bone density compared to the general population. METHODS: Long-term breast cancer survivors who had been treated for more than 5 years were selected for this study. Data were obtained from medical records and using a questionnaire from the Korea National Health and Nutrition Examination Survey (KNHANES). An age-matched non-cancer control group was selected from the KNHANES records. Incidence of fracture and bone mineral density (BMD) were compared between the two groups. RESULTS: In total, 74 long-term breast cancer survivors and 296 non-cancer controls were evaluated. The incidence of fracture did not differ between the two groups (P=0.130). No differences were detected in lumbar BMD (P=0.051) following adjustment for body mass index, while hip BMD was significantly lower in breast cancer survivors (P=0.028). Chemotherapy and endocrine treatment were not related to low BMD in breast cancer survivors. In more than half of the survivors, the 10-year risk of osteoporotic fracture was less than 1%. CONCLUSION: Long-term breast cancer survivors had low bone density but a comparable risk of fracture compared to non-cancer age-matched controls. Further studies on the factors related to low bone density in long-term breast cancer survivors are required.