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Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer
PURPOSE: The present study compares the peri/postoperative and oncological outcomes of abdominoperineal resections (APR) and sphincter saving resection (SSR) for low lying rectal cancer. METHODS: Between January 2001 and December 2014, 176 patients who underwent SSR (n=67) and APR (n=109) for low re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Surgical Oncology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942753/ https://www.ncbi.nlm.nih.gov/pubmed/36945671 http://dx.doi.org/10.14216/kjco.21012 |
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author | Jo, Won Il Lim, Dae Ro Kuk, Jung Cheol Shin, Eung Jin |
author_facet | Jo, Won Il Lim, Dae Ro Kuk, Jung Cheol Shin, Eung Jin |
author_sort | Jo, Won Il |
collection | PubMed |
description | PURPOSE: The present study compares the peri/postoperative and oncological outcomes of abdominoperineal resections (APR) and sphincter saving resection (SSR) for low lying rectal cancer. METHODS: Between January 2001 and December 2014, 176 patients who underwent SSR (n=67) and APR (n=109) for low rectal cancer, without stage IV, were retrieved from a retrospective database. RESULTS: With a median follow-up of 66.5 months. The mean total number of harvested lymph nodes was 16.7 (SSR) versus 17.1 (APR) (P=0.801). The advanced T stage was higher in the APR group (82.6%) versus the SSR group (55.2%) (P=0.006). The positive rate of lymph nodes after surgery was significantly higher in the APR group (45.9%) versus SSR group (25.4%) (P<0.05). The 5-year overall survival rates for SSR and APR were 87.3% and 67.6%, respectively (P<0.005). The 5-year disease-free survival rate (DFS) was 83.6% (SSR) versus 65.5% (APR) (P=0.002). The recurrence rate was higher in the APR group (34.9%) versus the SSR group (14.9%) (P=0.004). Local recurrence rate was not different between the two groups. However, distant recurrence rate was significantly higher in the APR group (26.6% vs. 11.9%, P=0.023). In multivariate analysis, node positive (N0 vs. N1–2) was an independent prognostic factor for DFS (P<0.005). CONCLUSION: Based on the present data, SSR achieved better 5-year oncological outcome than APR. The positive lymph node ratio in the N stage after surgery was higher in the APR group and this seems to have an effect on the oncological outcomes of the APR group. |
format | Online Article Text |
id | pubmed-9942753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society of Surgical Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-99427532023-03-20 Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer Jo, Won Il Lim, Dae Ro Kuk, Jung Cheol Shin, Eung Jin Korean J Clin Oncol Original Article PURPOSE: The present study compares the peri/postoperative and oncological outcomes of abdominoperineal resections (APR) and sphincter saving resection (SSR) for low lying rectal cancer. METHODS: Between January 2001 and December 2014, 176 patients who underwent SSR (n=67) and APR (n=109) for low rectal cancer, without stage IV, were retrieved from a retrospective database. RESULTS: With a median follow-up of 66.5 months. The mean total number of harvested lymph nodes was 16.7 (SSR) versus 17.1 (APR) (P=0.801). The advanced T stage was higher in the APR group (82.6%) versus the SSR group (55.2%) (P=0.006). The positive rate of lymph nodes after surgery was significantly higher in the APR group (45.9%) versus SSR group (25.4%) (P<0.05). The 5-year overall survival rates for SSR and APR were 87.3% and 67.6%, respectively (P<0.005). The 5-year disease-free survival rate (DFS) was 83.6% (SSR) versus 65.5% (APR) (P=0.002). The recurrence rate was higher in the APR group (34.9%) versus the SSR group (14.9%) (P=0.004). Local recurrence rate was not different between the two groups. However, distant recurrence rate was significantly higher in the APR group (26.6% vs. 11.9%, P=0.023). In multivariate analysis, node positive (N0 vs. N1–2) was an independent prognostic factor for DFS (P<0.005). CONCLUSION: Based on the present data, SSR achieved better 5-year oncological outcome than APR. The positive lymph node ratio in the N stage after surgery was higher in the APR group and this seems to have an effect on the oncological outcomes of the APR group. Korean Society of Surgical Oncology 2021-12 2021-12-31 /pmc/articles/PMC9942753/ /pubmed/36945671 http://dx.doi.org/10.14216/kjco.21012 Text en Copyright © 2021 Korean Society of Surgical Oncology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jo, Won Il Lim, Dae Ro Kuk, Jung Cheol Shin, Eung Jin Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
title | Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
title_full | Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
title_fullStr | Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
title_full_unstemmed | Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
title_short | Comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
title_sort | comparison of oncologic outcome of abdominoperineal resection versus sphincter saving resection for low lying rectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942753/ https://www.ncbi.nlm.nih.gov/pubmed/36945671 http://dx.doi.org/10.14216/kjco.21012 |
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