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Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information
Propagating spatiotemporal neural patterns are widely evident across sensory, motor, and association cortical areas. However, it remains unclear whether any characteristics of neural propagation carry information about specific behavioral details. Here, we provide the first evidence for a link betwe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942811/ https://www.ncbi.nlm.nih.gov/pubmed/36652475 http://dx.doi.org/10.1073/pnas.2212227120 |
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author | Liang, Wei Balasubramanian, Karthikeyan Papadourakis, Vasileios Hatsopoulos, Nicholas G. |
author_facet | Liang, Wei Balasubramanian, Karthikeyan Papadourakis, Vasileios Hatsopoulos, Nicholas G. |
author_sort | Liang, Wei |
collection | PubMed |
description | Propagating spatiotemporal neural patterns are widely evident across sensory, motor, and association cortical areas. However, it remains unclear whether any characteristics of neural propagation carry information about specific behavioral details. Here, we provide the first evidence for a link between the direction of cortical propagation and specific behavioral features of an upcoming movement on a trial-by-trial basis. We recorded local field potentials (LFPs) from multielectrode arrays implanted in the primary motor cortex of two rhesus macaque monkeys while they performed a 2D reach task. Propagating patterns were extracted from the information-rich high-gamma band (200 to 400 Hz) envelopes in the LFP amplitude. We found that the exact direction of propagating patterns varied systematically according to initial movement direction, enabling kinematic predictions. Furthermore, characteristics of these propagation patterns provided additional predictive capability beyond the LFP amplitude themselves, which suggests the value of including mesoscopic spatiotemporal characteristics in refining brain–machine interfaces. |
format | Online Article Text |
id | pubmed-9942811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-99428112023-02-22 Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information Liang, Wei Balasubramanian, Karthikeyan Papadourakis, Vasileios Hatsopoulos, Nicholas G. Proc Natl Acad Sci U S A Biological Sciences Propagating spatiotemporal neural patterns are widely evident across sensory, motor, and association cortical areas. However, it remains unclear whether any characteristics of neural propagation carry information about specific behavioral details. Here, we provide the first evidence for a link between the direction of cortical propagation and specific behavioral features of an upcoming movement on a trial-by-trial basis. We recorded local field potentials (LFPs) from multielectrode arrays implanted in the primary motor cortex of two rhesus macaque monkeys while they performed a 2D reach task. Propagating patterns were extracted from the information-rich high-gamma band (200 to 400 Hz) envelopes in the LFP amplitude. We found that the exact direction of propagating patterns varied systematically according to initial movement direction, enabling kinematic predictions. Furthermore, characteristics of these propagation patterns provided additional predictive capability beyond the LFP amplitude themselves, which suggests the value of including mesoscopic spatiotemporal characteristics in refining brain–machine interfaces. National Academy of Sciences 2023-01-18 2023-01-24 /pmc/articles/PMC9942811/ /pubmed/36652475 http://dx.doi.org/10.1073/pnas.2212227120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Biological Sciences Liang, Wei Balasubramanian, Karthikeyan Papadourakis, Vasileios Hatsopoulos, Nicholas G. Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
title | Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
title_full | Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
title_fullStr | Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
title_full_unstemmed | Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
title_short | Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
title_sort | propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942811/ https://www.ncbi.nlm.nih.gov/pubmed/36652475 http://dx.doi.org/10.1073/pnas.2212227120 |
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