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Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, in which prognosis is determined by liver fibrosis. A common variant in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13, rs72613567-A) is associated with a reduced risk of fibrosis in NAFLD, but the underlying mecha...

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Detalles Bibliográficos
Autores principales:	Luukkonen, Panu K., Sakuma, Ikki, Gaspar, Rafael C., Mooring, Meghan, Nasiri, Ali, Kahn, Mario, Zhang, Xian-Man, Zhang, Dongyan, Sammalkorpi, Henna, Penttilä, Anne K., Orho-Melander, Marju, Arola, Johanna, Juuti, Anne, Zhang, Xuchen, Yimlamai, Dean, Yki-Järvinen, Hannele, Petersen, Kitt Falk, Shulman, Gerald I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942818/ https://www.ncbi.nlm.nih.gov/pubmed/36669104 http://dx.doi.org/10.1073/pnas.2217543120

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