Cargando…
Mammalian life depends on two distinct pathways of DNA damage tolerance
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of life, yet its relevance in mammals remains unclear...
Autores principales: | Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E. J., Vivié, Judith, Mcgrath, Kathleen E., Huijbers, Ivo J., Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L., Palis, James, van den Berk, Paul C. M., Jacobs, Heinz |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942833/ https://www.ncbi.nlm.nih.gov/pubmed/36669105 http://dx.doi.org/10.1073/pnas.2216055120 |
Ejemplares similares
-
PrimPol prevents APOBEC/AID family mediated DNA mutagenesis
por: Pilzecker, Bas, et al.
Publicado: (2016) -
DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy
por: Pilzecker, Bas, et al.
Publicado: (2019) -
It takes two to tango, and the right music: Synergistic drug combinations with cell-cycle phase-dependent sensitivities
por: Lieftink, Cor, et al.
Publicado: (2021) -
Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine
por: Spanjaard, Aldo, et al.
Publicado: (2022) -
Ribociclib Induces Broad Chemotherapy Resistance and EGFR Dependency in ESR1 Wildtype and Mutant Breast Cancer
por: Mayayo-Peralta, Isabel, et al.
Publicado: (2021)