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Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells

Mutations in IDH1, IDH2, and TET2 are recurrently observed in myeloid neoplasms. IDH1 and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the conversion of isocitrate to α-ketoglutarate (α-KG). Oncogenic IDH1/2 mutations confer neomorphic activity, leading to the production of...

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Detalles Bibliográficos
Autores principales:	Fortin, Jerome, Chiang, Ming-Feng, Meydan, Cem, Foox, Jonathan, Ramachandran, Parameswaran, Leca, Julie, Lemonnier, François, Li, Wanda Y., Gams, Miki S., Sakamoto, Takashi, Chu, Mandy, Tobin, Chantal, Laugesen, Eric, Robinson, Troy M., You-Ten, Annick, Butler, Daniel J., Berger, Thorsten, Minden, Mark D., Levine, Ross L., Guidos, Cynthia J., Melnick, Ari M., Mason, Christopher E., Mak, Tak W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942850/ https://www.ncbi.nlm.nih.gov/pubmed/36652477 http://dx.doi.org/10.1073/pnas.2208176120

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