Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that interrupt malaria parasite development in the mosquito, thereby blocking onward transmission, and provide a much-needed tool for malaria control and elimination. The parasite surface protein Pfs48/45 is a leading TBV candida...

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Autores principales: Fabra-García, Amanda, Hailemariam, Sophia, de Jong, Roos M., Janssen, Kirsten, Teelen, Karina, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Ivanochko, Danton, Semesi, Anthony, McLeod, Brandon, Vos, Martijn W., de Bruijni, Marloes H.C., Bolscher, Judith M., Szabat, Marta, Vogt, Stefanie, Kraft, Lucas, Duncan, Sherie, Kamya, Moses R., Feeney, Margaret E., Jagannathan, Prasanna, Greenhouse, Bryan, Dechering, Koen J., Sauerwein, Robert W., King, C. Richter, MacGill, Randall S., Bousema, Teun, Julien, Jean-Philippe, Jore, Matthijs M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942873/
https://www.ncbi.nlm.nih.gov/pubmed/36792574
http://dx.doi.org/10.1016/j.immuni.2023.01.009

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