Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230

Pfs230 is essential for Plasmodium falciparum transmission to mosquitoes and is the protein targeted by the most advanced malaria-transmission-blocking vaccine candidate. Prior understanding of functional epitopes on Pfs230 is based on two monoclonal antibodies (mAbs) with moderate transmission-redu...

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Detalles Bibliográficos
Autores principales: Ivanochko, Danton, Fabra-García, Amanda, Teelen, Karina, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Newton, Jocelyn, Semesi, Anthony, de Bruijni, Marloes, Bolscher, Judith, Ramjith, Jordache, Szabat, Marta, Vogt, Stefanie, Kraft, Lucas, Duncan, Sherie, Lee, Shwu-Maan, Kamya, Moses R., Feeney, Margaret E., Jagannathan, Prasanna, Greenhouse, Bryan, Sauerwein, Robert W., Richter King, C., MacGill, Randall S., Bousema, Teun, Jore, Matthijs M., Julien, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942874/
https://www.ncbi.nlm.nih.gov/pubmed/36792575
http://dx.doi.org/10.1016/j.immuni.2023.01.013

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