Base editing screens map mutations affecting interferon-γ signaling in cancer

Interferon-γ (IFN-γ) signaling mediates host responses to infection, inflammation and anti-tumor immunity. Mutations in the IFN-γ signaling pathway cause immunological disorders, hematological malignancies, and resistance to immune checkpoint blockade (ICB) in cancer; however, the function of most c...

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Detalles Bibliográficos
Autores principales: Coelho, Matthew A., Cooper, Sarah, Strauss, Magdalena E., Karakoc, Emre, Bhosle, Shriram, Gonçalves, Emanuel, Picco, Gabriele, Burgold, Thomas, Cattaneo, Chiara M., Veninga, Vivien, Consonni, Sarah, Dinçer, Cansu, Vieira, Sara F., Gibson, Freddy, Barthorpe, Syd, Hardy, Claire, Rein, Joel, Thomas, Mark, Marioni, John, Voest, Emile E., Bassett, Andrew, Garnett, Mathew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942875/
https://www.ncbi.nlm.nih.gov/pubmed/36669486
http://dx.doi.org/10.1016/j.ccell.2022.12.009

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