Metformin acts in the gut and induces gut-liver crosstalk

Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still not well established. Here, we investigated the effects of metformin on basolateral intestinal glucose uptake (BIGU), and its consequences on hepatic glucose production (HGP). In diabetic patients and mice,...

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Detalles Bibliográficos
Autores principales: Tobar, Natália, Rocha, Guilherme Z., Santos, Andrey, Guadagnini, Dioze, Assalin, Heloísa B., Camargo, Juliana A., Gonçalves, Any E. S. S., Pallis, Flavia R., Oliveira, Alexandre G., Rocco, Silvana A., Neto, Raphael M., de Sousa, Irene Layane, Alborghetti, Marcos R., Sforça, Maurício L., Rodrigues, Patrícia B., Ludwig, Raissa G., Vanzela, Emerielle C., Brunetto, Sergio Q., Boer, Patrícia A., Gontijo, José A. R., Geloneze, Bruno, Carvalho, Carla R. O., Prada, Patricia O., Folli, Franco, Curi, Rui, Mori, Marcelo A., Vinolo, Marco A. R., Ramos, Celso D., Franchini, Kleber G., Tormena, Claudio F., Saad, Mario J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942892/
https://www.ncbi.nlm.nih.gov/pubmed/36656866
http://dx.doi.org/10.1073/pnas.2211933120

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