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Cerebral cortical thinning in Parkinson’s disease depends on the age of onset

Patients with older-onset Parkinson’s disease (PD) have more severe motor symptoms, faster progression, and a worse prognosis. The thinning of the cerebral cortex is one of the causes of these issues. Patients with older-onset PD manifest more extended neurodegeneration associated with α-synuclein d...

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Autores principales: Seo, Kazuhide, Matunari, Ichiro, Yamamoto, Toshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942965/
https://www.ncbi.nlm.nih.gov/pubmed/36809440
http://dx.doi.org/10.1371/journal.pone.0281987
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author Seo, Kazuhide
Matunari, Ichiro
Yamamoto, Toshimasa
author_facet Seo, Kazuhide
Matunari, Ichiro
Yamamoto, Toshimasa
author_sort Seo, Kazuhide
collection PubMed
description Patients with older-onset Parkinson’s disease (PD) have more severe motor symptoms, faster progression, and a worse prognosis. The thinning of the cerebral cortex is one of the causes of these issues. Patients with older-onset PD manifest more extended neurodegeneration associated with α-synuclein deposition in the cerebral cortex; however, the cortical regions that undergo thinning are unclear. We aimed to identify cortical regions with different thinning depending on the age of onset in patients with PD. Sixty-two patients with PD were included in this study. Patients with PD onset at <63 years old were included in the early or middle-onset PD group, and those with PD onset at >63 years old were included in the late-onset PD (LOPD) group. Brain magnetic resonance imaging data of these patients were processed using FreeSurfer to measure their cortical thickness. The LOPD group displayed less cortical thickness in the superior frontal gyrus, middle frontal gyrus, precentral gyrus, postcentral gyrus, superior temporal gyrus, temporal pole, paracentral lobule, superior parietal lobule, precuneus, and occipital lobe than the early or middle-onset PD group. Compared with patients with early and middle-onset PD, elderly patients displayed extended cortical thinning with disease progression. Differences in the clinical manifestations of PD according to the age of onset were partly due to variations in the morphological changes in the brain.
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spelling pubmed-99429652023-02-22 Cerebral cortical thinning in Parkinson’s disease depends on the age of onset Seo, Kazuhide Matunari, Ichiro Yamamoto, Toshimasa PLoS One Research Article Patients with older-onset Parkinson’s disease (PD) have more severe motor symptoms, faster progression, and a worse prognosis. The thinning of the cerebral cortex is one of the causes of these issues. Patients with older-onset PD manifest more extended neurodegeneration associated with α-synuclein deposition in the cerebral cortex; however, the cortical regions that undergo thinning are unclear. We aimed to identify cortical regions with different thinning depending on the age of onset in patients with PD. Sixty-two patients with PD were included in this study. Patients with PD onset at <63 years old were included in the early or middle-onset PD group, and those with PD onset at >63 years old were included in the late-onset PD (LOPD) group. Brain magnetic resonance imaging data of these patients were processed using FreeSurfer to measure their cortical thickness. The LOPD group displayed less cortical thickness in the superior frontal gyrus, middle frontal gyrus, precentral gyrus, postcentral gyrus, superior temporal gyrus, temporal pole, paracentral lobule, superior parietal lobule, precuneus, and occipital lobe than the early or middle-onset PD group. Compared with patients with early and middle-onset PD, elderly patients displayed extended cortical thinning with disease progression. Differences in the clinical manifestations of PD according to the age of onset were partly due to variations in the morphological changes in the brain. Public Library of Science 2023-02-21 /pmc/articles/PMC9942965/ /pubmed/36809440 http://dx.doi.org/10.1371/journal.pone.0281987 Text en © 2023 Seo et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Seo, Kazuhide
Matunari, Ichiro
Yamamoto, Toshimasa
Cerebral cortical thinning in Parkinson’s disease depends on the age of onset
title Cerebral cortical thinning in Parkinson’s disease depends on the age of onset
title_full Cerebral cortical thinning in Parkinson’s disease depends on the age of onset
title_fullStr Cerebral cortical thinning in Parkinson’s disease depends on the age of onset
title_full_unstemmed Cerebral cortical thinning in Parkinson’s disease depends on the age of onset
title_short Cerebral cortical thinning in Parkinson’s disease depends on the age of onset
title_sort cerebral cortical thinning in parkinson’s disease depends on the age of onset
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942965/
https://www.ncbi.nlm.nih.gov/pubmed/36809440
http://dx.doi.org/10.1371/journal.pone.0281987
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