The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

UHRF1-dependent ubiquitin signaling plays an integral role in the regulation of maintenance DNA methylation. UHRF1 catalyzes transient dual mono-ubiquitylation of PAF15 (PAF15Ub2), which regulates the localization and activation of DNMT1 at DNA methylation sites during DNA replication. Although the...

Descripción completa

Detalles Bibliográficos
Autores principales: Miyashita, Ryota, Nishiyama, Atsuya, Qin, Weihua, Chiba, Yoshie, Kori, Satomi, Kato, Norie, Konishi, Chieko, Kumamoto, Soichiro, Kozuka-Hata, Hiroko, Oyama, Masaaki, Kawasoe, Yoshitaka, Tsurimoto, Toshiki, Takahashi, Tatsuro S, Leonhardt, Heinrich, Arita, Kyohei, Nakanishi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943068/
https://www.ncbi.nlm.nih.gov/pubmed/36734974
http://dx.doi.org/10.7554/eLife.79013

Ejemplares similares

Ejemplares similares