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Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population

INTRODUCTION: LAMA1, also known as laminin subunit α1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between LAMA1sin...

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Autores principales: Zhang, Shaoyuan, Fang, Yong, Su, Feng, Jiang, Tian, Yu, Jinjie, Lin, Siyun, Lv, Lu, Long, Tao, Pan, Huiwen, Qi, Junqing, Zhou, Qiang, Tang, Weifeng, Ding, Guowen, Wang, Liming, Tan, Lijie, Yin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943613/
https://www.ncbi.nlm.nih.gov/pubmed/36824663
http://dx.doi.org/10.1155/2023/6922909
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author Zhang, Shaoyuan
Fang, Yong
Su, Feng
Jiang, Tian
Yu, Jinjie
Lin, Siyun
Lv, Lu
Long, Tao
Pan, Huiwen
Qi, Junqing
Zhou, Qiang
Tang, Weifeng
Ding, Guowen
Wang, Liming
Tan, Lijie
Yin, Jun
author_facet Zhang, Shaoyuan
Fang, Yong
Su, Feng
Jiang, Tian
Yu, Jinjie
Lin, Siyun
Lv, Lu
Long, Tao
Pan, Huiwen
Qi, Junqing
Zhou, Qiang
Tang, Weifeng
Ding, Guowen
Wang, Liming
Tan, Lijie
Yin, Jun
author_sort Zhang, Shaoyuan
collection PubMed
description INTRODUCTION: LAMA1, also known as laminin subunit α1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between LAMA1single-nucleotide polymorphisms and the occurrence and progression of esophageal squamous cell carcinoma in the Chinese population. METHOD: 2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of LAMA1 were selected and examined. We analyzed the association of several genetic models of 6 LAMA1 SNP loci, sex, age, smoking and drinking status, and the occurrence of esophageal squamous cell carcinoma. RESULTS: In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, P=0.046), especially among the younger and nondrinkers. At rs607230 T > C, genotype TC was linked with a lower risk of ESCC compared with TT. (OR: 0.613, P=0.034). Haplotype Frequencies revealed that A(rs62081531)G(rs621993)A(rs539713)T(rs566655)A(rs73938538)C(rs607230) (OR: 0.803, P=0.028) and G(rs62081531)G(rs621993)A(rs539713)T(rs566655)C(rs73938538)C(rs607230) (OR: 0.679, P=0.010) were strongly associated with lower susceptibility of ESCC. CONCLUSION: The LAMA1 rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. LAMA1 SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers.
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spelling pubmed-99436132023-02-22 Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population Zhang, Shaoyuan Fang, Yong Su, Feng Jiang, Tian Yu, Jinjie Lin, Siyun Lv, Lu Long, Tao Pan, Huiwen Qi, Junqing Zhou, Qiang Tang, Weifeng Ding, Guowen Wang, Liming Tan, Lijie Yin, Jun J Oncol Research Article INTRODUCTION: LAMA1, also known as laminin subunit α1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between LAMA1single-nucleotide polymorphisms and the occurrence and progression of esophageal squamous cell carcinoma in the Chinese population. METHOD: 2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of LAMA1 were selected and examined. We analyzed the association of several genetic models of 6 LAMA1 SNP loci, sex, age, smoking and drinking status, and the occurrence of esophageal squamous cell carcinoma. RESULTS: In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, P=0.046), especially among the younger and nondrinkers. At rs607230 T > C, genotype TC was linked with a lower risk of ESCC compared with TT. (OR: 0.613, P=0.034). Haplotype Frequencies revealed that A(rs62081531)G(rs621993)A(rs539713)T(rs566655)A(rs73938538)C(rs607230) (OR: 0.803, P=0.028) and G(rs62081531)G(rs621993)A(rs539713)T(rs566655)C(rs73938538)C(rs607230) (OR: 0.679, P=0.010) were strongly associated with lower susceptibility of ESCC. CONCLUSION: The LAMA1 rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. LAMA1 SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers. Hindawi 2023-02-14 /pmc/articles/PMC9943613/ /pubmed/36824663 http://dx.doi.org/10.1155/2023/6922909 Text en Copyright © 2023 Shaoyuan Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Shaoyuan
Fang, Yong
Su, Feng
Jiang, Tian
Yu, Jinjie
Lin, Siyun
Lv, Lu
Long, Tao
Pan, Huiwen
Qi, Junqing
Zhou, Qiang
Tang, Weifeng
Ding, Guowen
Wang, Liming
Tan, Lijie
Yin, Jun
Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population
title Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population
title_full Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population
title_fullStr Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population
title_full_unstemmed Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population
title_short Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population
title_sort association of lama1 single-nucleotide polymorphisms with risk of esophageal squamous cell carcinoma among the eastern chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943613/
https://www.ncbi.nlm.nih.gov/pubmed/36824663
http://dx.doi.org/10.1155/2023/6922909
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