Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding

The DNA mismatch repair protein MutSα recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation V63E in MSH2 that was found in the germline of a patient w...

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Detalles Bibliográficos
Autores principales: Bruekner, Susanne R, Pieters, Wietske, Fish, Alexander, Liaci, A Manuel, Scheffers, Serge, Rayner, Emily, Kaldenbach, Daphne, Drost, Lisa, Dekker, Marleen, van Hees-Stuivenberg, Sandrine, Delzenne-Goette, Elly, de Konink, Charlotte, Houlleberghs, Hellen, Dubbink, Hendrikus Jan, AlSaegh, Abeer, de Wind, Niels, Förster, Friedrich, te Riele, Hein, Sixma, Titia K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943660/
https://www.ncbi.nlm.nih.gov/pubmed/36715327
http://dx.doi.org/10.1093/nar/gkad015

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