Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function

Loss of gene function can be compensated by paralogs with redundant functions. An example of such compensation are the paralogs of the Muscleblind-Like (MBNL) family of RNA-binding proteins that are sequestered and lose their function in Myotonic Dystrophy Type 1 (DM1). Loss of MBNL1 increases the l...

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Detalles Bibliográficos
Autores principales: Nitschke, Larissa, Hu, Rong-Chi, Miller, Andrew N, Lucas, Lathan, Cooper, Thomas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943662/
https://www.ncbi.nlm.nih.gov/pubmed/36617982
http://dx.doi.org/10.1093/nar/gkac1219

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