Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism

DNA glycosylase MutY plays a critical role in suppression of mutations resulted from oxidative damage, as highlighted by cancer-association of the human enzyme. MutY requires a highly conserved catalytic Asp residue for excision of adenines misinserted opposite 8-oxo-7,8-dihydroguanine (OG). A nearb...

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Detalles Bibliográficos
Autores principales: Demir, Merve, Russelburg, L Peyton, Lin, Wen-Jen, Trasviña-Arenas, Carlos H, Huang, Beili, Yuen, Philip K, Horvath, Martin P, David, Sheila S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943663/
https://www.ncbi.nlm.nih.gov/pubmed/36631987
http://dx.doi.org/10.1093/nar/gkac1246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943663/
https://www.ncbi.nlm.nih.gov/pubmed/36631987
http://dx.doi.org/10.1093/nar/gkac1246

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