The homeodomain of Oct4 is a dimeric binder of methylated CpG elements

Oct4 is essential to maintain pluripotency and has a pivotal role in establishing the germline. Its DNA-binding POU domain was recently found to bind motifs with methylated CpG elements normally associated with epigenetic silencing. However, the mode of binding and the consequences of this capabilit...

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Detalles Bibliográficos
Autores principales: Tan, Daisylyn Senna, Cheung, Shun Lai, Gao, Ya, Weinbuch, Maike, Hu, Haoqing, Shi, Liyang, Ti, Shih-Chieh, Hutchins, Andrew P, Cojocaru, Vlad, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943670/
https://www.ncbi.nlm.nih.gov/pubmed/36631980
http://dx.doi.org/10.1093/nar/gkac1262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943670/
https://www.ncbi.nlm.nih.gov/pubmed/36631980
http://dx.doi.org/10.1093/nar/gkac1262

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