Structures of human TR4(LBD)–JAZF1 and TR4(DBD)–DNA complexes reveal the molecular basis of transcriptional regulation

Testicular nuclear receptor 4 (TR4) modulates the transcriptional activation of genes and plays important roles in many diseases. The regulation of TR4 on target genes involves direct interactions with DNA molecules via the DNA-binding domain (DBD) and recruitment of coregulators by the ligand-bindi...

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Detalles Bibliográficos
Autores principales: Liu, Yunlong, Ma, Lulu, Li, Min, Tian, Zizi, Yang, Meiting, Wu, Xi, Wang, Xue, Shang, Guohui, Xie, Mengjia, Chen, Yiyun, Liu, Xin, Jiang, Lun, Wu, Wei, Xu, Chaoqun, Xia, Liqun, Li, Gonghui, Dai, Shaodong, Chen, Zhongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943680/
https://www.ncbi.nlm.nih.gov/pubmed/36651297
http://dx.doi.org/10.1093/nar/gkac1259

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