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Essential terminology and considerations for validation of non-targeted methods

Through their suggestive name, non-targeted methods (NTMs) do not aim at a predefined “needle in the haystack.” Instead, they exploit all the constituents of the haystack. This new type of analytical method is increasingly finding applications in food and feed testing. However, the concepts, terms,...

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Autores principales: Nichani, Kapil, Uhlig, Steffen, Stoyke, Manfred, Kemmlein, Sabine, Ulberth, Franz, Haase, Ilka, Döring, Maik, Walch, Stephan G, Gowik, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943841/
https://www.ncbi.nlm.nih.gov/pubmed/36845497
http://dx.doi.org/10.1016/j.fochx.2022.100538
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author Nichani, Kapil
Uhlig, Steffen
Stoyke, Manfred
Kemmlein, Sabine
Ulberth, Franz
Haase, Ilka
Döring, Maik
Walch, Stephan G
Gowik, Petra
author_facet Nichani, Kapil
Uhlig, Steffen
Stoyke, Manfred
Kemmlein, Sabine
Ulberth, Franz
Haase, Ilka
Döring, Maik
Walch, Stephan G
Gowik, Petra
author_sort Nichani, Kapil
collection PubMed
description Through their suggestive name, non-targeted methods (NTMs) do not aim at a predefined “needle in the haystack.” Instead, they exploit all the constituents of the haystack. This new type of analytical method is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing need to be propagated for the benefit of those associated with academic research, commercial development, or official control. This paper addresses frequently asked questions regarding terminology in connection with NTMs. The widespread development and adoption of these methods also necessitate the need to develop innovative approaches for NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap for approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions therefor.
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spelling pubmed-99438412023-02-23 Essential terminology and considerations for validation of non-targeted methods Nichani, Kapil Uhlig, Steffen Stoyke, Manfred Kemmlein, Sabine Ulberth, Franz Haase, Ilka Döring, Maik Walch, Stephan G Gowik, Petra Food Chem X Article(s) from the Special Issue on Food Authentication and Origin by Dr. Yong Fang and Dr. Vural Gökmen Through their suggestive name, non-targeted methods (NTMs) do not aim at a predefined “needle in the haystack.” Instead, they exploit all the constituents of the haystack. This new type of analytical method is increasingly finding applications in food and feed testing. However, the concepts, terms, and considerations related to this burgeoning field of analytical testing need to be propagated for the benefit of those associated with academic research, commercial development, or official control. This paper addresses frequently asked questions regarding terminology in connection with NTMs. The widespread development and adoption of these methods also necessitate the need to develop innovative approaches for NTM validation, i.e., evaluating the performance characteristics of a method to determine if it is fit-for-purpose. This work aims to provide a roadmap for approaching NTM validation. In doing so, the paper deliberates on the different considerations that influence the approach to validation and provides suggestions therefor. Elsevier 2022-12-10 /pmc/articles/PMC9943841/ /pubmed/36845497 http://dx.doi.org/10.1016/j.fochx.2022.100538 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article(s) from the Special Issue on Food Authentication and Origin by Dr. Yong Fang and Dr. Vural Gökmen
Nichani, Kapil
Uhlig, Steffen
Stoyke, Manfred
Kemmlein, Sabine
Ulberth, Franz
Haase, Ilka
Döring, Maik
Walch, Stephan G
Gowik, Petra
Essential terminology and considerations for validation of non-targeted methods
title Essential terminology and considerations for validation of non-targeted methods
title_full Essential terminology and considerations for validation of non-targeted methods
title_fullStr Essential terminology and considerations for validation of non-targeted methods
title_full_unstemmed Essential terminology and considerations for validation of non-targeted methods
title_short Essential terminology and considerations for validation of non-targeted methods
title_sort essential terminology and considerations for validation of non-targeted methods
topic Article(s) from the Special Issue on Food Authentication and Origin by Dr. Yong Fang and Dr. Vural Gökmen
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943841/
https://www.ncbi.nlm.nih.gov/pubmed/36845497
http://dx.doi.org/10.1016/j.fochx.2022.100538
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