Melatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR

The physiological crosstalk between glucocorticoid and melatonin maintains neuronal homeostasis in regulating circadian rhythms. However, the stress-inducing level of glucocorticoid triggers mitochondrial dysfunction including defective mitophagy by increasing the activity of glucocorticoid receptor...

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Detalles Bibliográficos
Autores principales: Kim, Min Jeong, Choi, Gee Euhn, Chae, Chang Woo, Lim, Jae Ryong, Jung, Young Hyun, Yoon, Jee Hyeon, Park, Ji Yong, Han, Ho Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943853/
https://www.ncbi.nlm.nih.gov/pubmed/36810730
http://dx.doi.org/10.1038/s41419-023-05676-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943853/
https://www.ncbi.nlm.nih.gov/pubmed/36810730
http://dx.doi.org/10.1038/s41419-023-05676-5

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