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Assembly chaperone Nas6 selectively destabilizes 26S proteasomes with defective regulatory particle-core particle interfaces

The 26S proteasome is a 66-subunit–chambered protease present in all eukaryotes that maintains organismal health by degrading unneeded or defective proteins. Defects in proteasome function or assembly are known to contribute to the development of various cancers, neurodegeneration, and diabetes. Dur...

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Detalles Bibliográficos
Autores principales:	Warnock, Jennifer L., Jobin, Gabriel W., Kumar, Sandhya, Tomko, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943895/ https://www.ncbi.nlm.nih.gov/pubmed/36634850 http://dx.doi.org/10.1016/j.jbc.2023.102894

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