Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function

Extracellular dopamine (DA) levels are constrained by the presynaptic DA transporter (DAT), a major psychostimulant target. Despite its necessity for DA neurotransmission, DAT regulation in situ is poorly understood, and it is unknown whether regulated DAT trafficking impacts dopaminergic signaling...

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Detalles Bibliográficos
Autores principales: Kearney, Patrick J., Bolden, Nicholas C., Kahuno, Elizabeth, Conklin, Tucker L., Martin, Gilles E., Lubec, Gert, Melikian, Haley E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943899/
https://www.ncbi.nlm.nih.gov/pubmed/36640864
http://dx.doi.org/10.1016/j.jbc.2023.102900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9943899/
https://www.ncbi.nlm.nih.gov/pubmed/36640864
http://dx.doi.org/10.1016/j.jbc.2023.102900

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