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Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure

In medical validation experiments, such as drug testing and clinical trials, 3D bioprinted biomimetic tissues, especially those containing blood vessels, can be used to replace animal models. The difficulty in the viability of printed biomimetic tissues, in general, lies in the provision of adequate...

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Autores principales: Shi, Jianping, Wei, Fuyin, Chouraki, Bilal, Sun, Xianglong, Wei, Jiayu, Zhu, Liya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944109/
https://www.ncbi.nlm.nih.gov/pubmed/36810400
http://dx.doi.org/10.3390/biomimetics8010069
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author Shi, Jianping
Wei, Fuyin
Chouraki, Bilal
Sun, Xianglong
Wei, Jiayu
Zhu, Liya
author_facet Shi, Jianping
Wei, Fuyin
Chouraki, Bilal
Sun, Xianglong
Wei, Jiayu
Zhu, Liya
author_sort Shi, Jianping
collection PubMed
description In medical validation experiments, such as drug testing and clinical trials, 3D bioprinted biomimetic tissues, especially those containing blood vessels, can be used to replace animal models. The difficulty in the viability of printed biomimetic tissues, in general, lies in the provision of adequate oxygen and nutrients to the internal regions. This is to ensure normal cellular metabolic activity. The construction of a flow channel network in the tissue is an effective way to address this challenge by both allowing nutrients to diffuse and providing sufficient nutrients for internal cell growth and by removing metabolic waste in a timely manner. In this paper, a three-dimensional TPMS vascular flow channel network model was developed and simulated to analyse the effect of perfusion pressure on blood flow rate and vascular-like flow channel wall pressure when the perfusion pressure varies. Based on the simulation results, the in vitro perfusion culture parameters were optimised to improve the structure of the porous structure model of the vascular-like flow channel, avoiding perfusion failure due to unreasonable perfusion pressure settings or necrosis of cells without sufficient nutrients due to the lack of fluid passing through some of the channels, and the research work promotes the development of tissue engineering in vitro culture.
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spelling pubmed-99441092023-02-23 Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure Shi, Jianping Wei, Fuyin Chouraki, Bilal Sun, Xianglong Wei, Jiayu Zhu, Liya Biomimetics (Basel) Article In medical validation experiments, such as drug testing and clinical trials, 3D bioprinted biomimetic tissues, especially those containing blood vessels, can be used to replace animal models. The difficulty in the viability of printed biomimetic tissues, in general, lies in the provision of adequate oxygen and nutrients to the internal regions. This is to ensure normal cellular metabolic activity. The construction of a flow channel network in the tissue is an effective way to address this challenge by both allowing nutrients to diffuse and providing sufficient nutrients for internal cell growth and by removing metabolic waste in a timely manner. In this paper, a three-dimensional TPMS vascular flow channel network model was developed and simulated to analyse the effect of perfusion pressure on blood flow rate and vascular-like flow channel wall pressure when the perfusion pressure varies. Based on the simulation results, the in vitro perfusion culture parameters were optimised to improve the structure of the porous structure model of the vascular-like flow channel, avoiding perfusion failure due to unreasonable perfusion pressure settings or necrosis of cells without sufficient nutrients due to the lack of fluid passing through some of the channels, and the research work promotes the development of tissue engineering in vitro culture. MDPI 2023-02-06 /pmc/articles/PMC9944109/ /pubmed/36810400 http://dx.doi.org/10.3390/biomimetics8010069 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Jianping
Wei, Fuyin
Chouraki, Bilal
Sun, Xianglong
Wei, Jiayu
Zhu, Liya
Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
title Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
title_full Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
title_fullStr Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
title_full_unstemmed Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
title_short Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure
title_sort study on performance simulation of vascular-like flow channel model based on tpms structure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944109/
https://www.ncbi.nlm.nih.gov/pubmed/36810400
http://dx.doi.org/10.3390/biomimetics8010069
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