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Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report

Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes. Panretinal photocoagulation (PRP) and anti-vascular endothelial growth factor (anti-VEGF) are approved treatment modalities aimed at regressing neovascularization. Data are lacking about abnormalities in retin...

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Autores principales: Rahimi, Mansour, Kashani, Amir H., Blair, Norman P., Shahidi, Mahnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944214/
https://www.ncbi.nlm.nih.gov/pubmed/36845454
http://dx.doi.org/10.1159/000526569
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author Rahimi, Mansour
Kashani, Amir H.
Blair, Norman P.
Shahidi, Mahnaz
author_facet Rahimi, Mansour
Kashani, Amir H.
Blair, Norman P.
Shahidi, Mahnaz
author_sort Rahimi, Mansour
collection PubMed
description Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes. Panretinal photocoagulation (PRP) and anti-vascular endothelial growth factor (anti-VEGF) are approved treatment modalities aimed at regressing neovascularization. Data are lacking about abnormalities in retinal vascular and oxygen metrics before and after combination treatments. A 32-year-old Caucasian male diagnosed with PDR in the right eye was treated by a combination of PRP and multiple anti-VEGF treatments over a 12-month period. The subject underwent optical coherence tomography (OCT) angiography, Doppler OCT, and retinal oximetry before treatment and at 12 months, which was 6 months following the last treatment. Measurements of vascular metrics (vessel density [VD] and mean arterial and venous diameters [D(A), D(V)]) and oxygen metrics (total retinal blood flow [TRBF], inner retinal oxygen delivery [DO(2)], metabolism [MO(2)], and extraction fraction [OEF]) were obtained. Both before and after treatments, VD, TRBF, MO(2), and DO(2) were below the normal lower confidence limits. Additionally, D(V) and OEF were decreased after treatments. Alterations in retinal vascular and oxygen metrics were reported for the first time in untreated and treated PDR. Future studies are warranted to evaluate the clinical value of these metrics in PDR.
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spelling pubmed-99442142023-02-23 Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report Rahimi, Mansour Kashani, Amir H. Blair, Norman P. Shahidi, Mahnaz Case Rep Ophthalmol Case Report Proliferative diabetic retinopathy (PDR) is a vision-threatening complication of diabetes. Panretinal photocoagulation (PRP) and anti-vascular endothelial growth factor (anti-VEGF) are approved treatment modalities aimed at regressing neovascularization. Data are lacking about abnormalities in retinal vascular and oxygen metrics before and after combination treatments. A 32-year-old Caucasian male diagnosed with PDR in the right eye was treated by a combination of PRP and multiple anti-VEGF treatments over a 12-month period. The subject underwent optical coherence tomography (OCT) angiography, Doppler OCT, and retinal oximetry before treatment and at 12 months, which was 6 months following the last treatment. Measurements of vascular metrics (vessel density [VD] and mean arterial and venous diameters [D(A), D(V)]) and oxygen metrics (total retinal blood flow [TRBF], inner retinal oxygen delivery [DO(2)], metabolism [MO(2)], and extraction fraction [OEF]) were obtained. Both before and after treatments, VD, TRBF, MO(2), and DO(2) were below the normal lower confidence limits. Additionally, D(V) and OEF were decreased after treatments. Alterations in retinal vascular and oxygen metrics were reported for the first time in untreated and treated PDR. Future studies are warranted to evaluate the clinical value of these metrics in PDR. S. Karger AG 2022-09-19 /pmc/articles/PMC9944214/ /pubmed/36845454 http://dx.doi.org/10.1159/000526569 Text en Copyright © 2022 by The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Rahimi, Mansour
Kashani, Amir H.
Blair, Norman P.
Shahidi, Mahnaz
Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report
title Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report
title_full Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report
title_fullStr Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report
title_full_unstemmed Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report
title_short Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report
title_sort alterations in retinal vascular and oxygen metrics in treated and untreated proliferative diabetic retinopathy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944214/
https://www.ncbi.nlm.nih.gov/pubmed/36845454
http://dx.doi.org/10.1159/000526569
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