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Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff

Dandruff is a common scalp disorder with multiple microbial and host-related factors contributing to its aetiology, including alterations in scalp sebum. Despite existing evidence that the yeast Malassezia restricta plays a key role in the onset of dandruff, the interplay of these factors is poorly...

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Autores principales: JOURDAIN, Roland, MOGA, Alain, MAGIATIS, Prokopios, FONTANIÉ, Maxime, VELEGRAKI, Aristea, PAPADIMOU, Chrysanthi, RAHOUL, Valérie, GUÉNICHE, Audrey, CHOPRA, Tarun, GAITANIS, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical Journals Sweden, on behalf of the Society for Publication of Acta Dermato-Venereologica 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944333/
https://www.ncbi.nlm.nih.gov/pubmed/36789756
http://dx.doi.org/10.2340/actadv.v103.4808
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author JOURDAIN, Roland
MOGA, Alain
MAGIATIS, Prokopios
FONTANIÉ, Maxime
VELEGRAKI, Aristea
PAPADIMOU, Chrysanthi
RAHOUL, Valérie
GUÉNICHE, Audrey
CHOPRA, Tarun
GAITANIS, George
author_facet JOURDAIN, Roland
MOGA, Alain
MAGIATIS, Prokopios
FONTANIÉ, Maxime
VELEGRAKI, Aristea
PAPADIMOU, Chrysanthi
RAHOUL, Valérie
GUÉNICHE, Audrey
CHOPRA, Tarun
GAITANIS, George
author_sort JOURDAIN, Roland
collection PubMed
description Dandruff is a common scalp disorder with multiple microbial and host-related factors contributing to its aetiology, including alterations in scalp sebum. Despite existing evidence that the yeast Malassezia restricta plays a key role in the onset of dandruff, the interplay of these factors is poorly understood. Recently, squalene monohydroperoxide and malondialdehyde were established as biomarkers of dandruff-afflicted scalp, highlighting the role of sebum lipoperoxidation in the triggering and maintenance of dandruff, although its mechanism of action is unknown. The current study provides evidence that M. restricta mediates sebum peroxidation, leading to production of squalene monohydroperoxide and malondialdehyde. Furthermore, in vitro data show that these lipoperoxidation products act on epidermal cells and alter the skin barrier. These results support the role of Malassezia restricta-induced lipoperoxides as triggers of dandruff, which suggests that blocking their production could be a novel anti-dandruff treatment approach.
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spelling pubmed-99443332023-02-23 Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff JOURDAIN, Roland MOGA, Alain MAGIATIS, Prokopios FONTANIÉ, Maxime VELEGRAKI, Aristea PAPADIMOU, Chrysanthi RAHOUL, Valérie GUÉNICHE, Audrey CHOPRA, Tarun GAITANIS, George Acta Derm Venereol Original Report Dandruff is a common scalp disorder with multiple microbial and host-related factors contributing to its aetiology, including alterations in scalp sebum. Despite existing evidence that the yeast Malassezia restricta plays a key role in the onset of dandruff, the interplay of these factors is poorly understood. Recently, squalene monohydroperoxide and malondialdehyde were established as biomarkers of dandruff-afflicted scalp, highlighting the role of sebum lipoperoxidation in the triggering and maintenance of dandruff, although its mechanism of action is unknown. The current study provides evidence that M. restricta mediates sebum peroxidation, leading to production of squalene monohydroperoxide and malondialdehyde. Furthermore, in vitro data show that these lipoperoxidation products act on epidermal cells and alter the skin barrier. These results support the role of Malassezia restricta-induced lipoperoxides as triggers of dandruff, which suggests that blocking their production could be a novel anti-dandruff treatment approach. Medical Journals Sweden, on behalf of the Society for Publication of Acta Dermato-Venereologica 2023-02-15 /pmc/articles/PMC9944333/ /pubmed/36789756 http://dx.doi.org/10.2340/actadv.v103.4808 Text en © 2023 Acta Dermato-Venereologica https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Report
JOURDAIN, Roland
MOGA, Alain
MAGIATIS, Prokopios
FONTANIÉ, Maxime
VELEGRAKI, Aristea
PAPADIMOU, Chrysanthi
RAHOUL, Valérie
GUÉNICHE, Audrey
CHOPRA, Tarun
GAITANIS, George
Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
title Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
title_full Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
title_fullStr Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
title_full_unstemmed Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
title_short Malassezia restricta-mediated Lipoperoxidation: A Novel Trigger in Dandruff
title_sort malassezia restricta-mediated lipoperoxidation: a novel trigger in dandruff
topic Original Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944333/
https://www.ncbi.nlm.nih.gov/pubmed/36789756
http://dx.doi.org/10.2340/actadv.v103.4808
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