Mechanisms of paeoniaceae action as an antidepressant

Paeoniflorin (PF) has been widely used for the treatment of depression in mice models, some Chinese herbal compound containing PF on treating depression, such as Xiaoyao San, Chaihu-Shugan-San, Danggui Shaoyao San etc. Many experiments are also verifying whether PF in these powders can be used as an...

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Autores principales: Guo, Wanxu, Yao, Xiaoxiao, Cui, Ranji, Yang, Wei, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944447/
https://www.ncbi.nlm.nih.gov/pubmed/36844911
http://dx.doi.org/10.3389/fphar.2022.934199
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author Guo, Wanxu
Yao, Xiaoxiao
Cui, Ranji
Yang, Wei
Wang, Lei
author_facet Guo, Wanxu
Yao, Xiaoxiao
Cui, Ranji
Yang, Wei
Wang, Lei
author_sort Guo, Wanxu
collection PubMed
description Paeoniflorin (PF) has been widely used for the treatment of depression in mice models, some Chinese herbal compound containing PF on treating depression, such as Xiaoyao San, Chaihu-Shugan-San, Danggui Shaoyao San etc. Many experiments are also verifying whether PF in these powders can be used as an effective component in the treatment of depression. Therefore, in this review the antidepressant effect of PF and its mechanism of action are outlined with particular focus on the following aspects: increasing the levels of monoamine neurotransmitters, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of brain-derived neurotrophic factor (BDNF). This review may be helpful for the application of PF in the treatment of depression.
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spelling pubmed-99444472023-02-23 Mechanisms of paeoniaceae action as an antidepressant Guo, Wanxu Yao, Xiaoxiao Cui, Ranji Yang, Wei Wang, Lei Front Pharmacol Pharmacology Paeoniflorin (PF) has been widely used for the treatment of depression in mice models, some Chinese herbal compound containing PF on treating depression, such as Xiaoyao San, Chaihu-Shugan-San, Danggui Shaoyao San etc. Many experiments are also verifying whether PF in these powders can be used as an effective component in the treatment of depression. Therefore, in this review the antidepressant effect of PF and its mechanism of action are outlined with particular focus on the following aspects: increasing the levels of monoamine neurotransmitters, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating levels of brain-derived neurotrophic factor (BDNF). This review may be helpful for the application of PF in the treatment of depression. Frontiers Media S.A. 2023-02-08 /pmc/articles/PMC9944447/ /pubmed/36844911 http://dx.doi.org/10.3389/fphar.2022.934199 Text en Copyright © 2023 Guo, Yao, Cui, Yang and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Guo, Wanxu
Yao, Xiaoxiao
Cui, Ranji
Yang, Wei
Wang, Lei
Mechanisms of paeoniaceae action as an antidepressant
title Mechanisms of paeoniaceae action as an antidepressant
title_full Mechanisms of paeoniaceae action as an antidepressant
title_fullStr Mechanisms of paeoniaceae action as an antidepressant
title_full_unstemmed Mechanisms of paeoniaceae action as an antidepressant
title_short Mechanisms of paeoniaceae action as an antidepressant
title_sort mechanisms of paeoniaceae action as an antidepressant
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944447/
https://www.ncbi.nlm.nih.gov/pubmed/36844911
http://dx.doi.org/10.3389/fphar.2022.934199
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AT cuiranji mechanismsofpaeoniaceaeactionasanantidepressant
AT yangwei mechanismsofpaeoniaceaeactionasanantidepressant
AT wanglei mechanismsofpaeoniaceaeactionasanantidepressant

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