Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH

It has been postulated that inflammasomes, in particular the NLRP3 (NLR family pyrin domain containing 3) inflammasome, mediate the necroinflammation and fibrosis that characterize nonalcoholic steatohepatitis (NASH) by engaging innate immune responses. We aimed to investigate the impact of genetic...

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Detalles Bibliográficos
Autores principales: Ioannou, George N., Horn, Christian L., Kothari, Vishal, Yeh, Matthew M., Shyu, Irene, Lee, Sum P., Savard, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944495/
https://www.ncbi.nlm.nih.gov/pubmed/36641116
http://dx.doi.org/10.1016/j.jlr.2023.100330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944495/
https://www.ncbi.nlm.nih.gov/pubmed/36641116
http://dx.doi.org/10.1016/j.jlr.2023.100330

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