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Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study

OBJECTIVES: To estimate the prevalence of long COVID symptoms in children with and without a history of SARS-CoV-2 infection and to evaluate factors associated with long COVID. DESIGN: A nationwide cross-sectional study. SETTING: Primary care. PARTICIPANTS: 3240 parents of children aged 5–18 with an...

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Autores principales: Adler, Limor, Israel, Moran, Yehoshua, Ilan, Azuri, Joseph, Hoffman, Robert, Shahar, Arnon, Mizrahi Reuveni, Miri, Grossman, Zachi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944622/
https://www.ncbi.nlm.nih.gov/pubmed/36810170
http://dx.doi.org/10.1136/bmjopen-2022-064155
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author Adler, Limor
Israel, Moran
Yehoshua, Ilan
Azuri, Joseph
Hoffman, Robert
Shahar, Arnon
Mizrahi Reuveni, Miri
Grossman, Zachi
author_facet Adler, Limor
Israel, Moran
Yehoshua, Ilan
Azuri, Joseph
Hoffman, Robert
Shahar, Arnon
Mizrahi Reuveni, Miri
Grossman, Zachi
author_sort Adler, Limor
collection PubMed
description OBJECTIVES: To estimate the prevalence of long COVID symptoms in children with and without a history of SARS-CoV-2 infection and to evaluate factors associated with long COVID. DESIGN: A nationwide cross-sectional study. SETTING: Primary care. PARTICIPANTS: 3240 parents of children aged 5–18 with and without SARS-CoV-2 infection completed an online questionnaire (11.9% response rate); 1148 and 2092 with/without a history of infection, respectively. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome was the prevalence of long COVID symptoms in children with/without a history of infection. Secondary outcomes were the factors associated with the presence of long COVID symptoms and with failure to return to baseline health status in children with a history of infection including gender, age, time from illness, symptomatic illness and vaccine status. RESULTS: Most long COVID symptoms were more prevalent in children with a history of SARS-CoV-2 infection: headaches (211 (18.4%) vs 114 (5.4%), p<0.001), weakness (173 (15.1%) vs 70 (3.3%), p<0.001), fatigue (141 (12.3%) vs 133 (6.4%), p<0.001) and abdominal pain (109 (9.5%) vs 79 (3.8%), p<0.001). Most long COVID symptoms in children with a history of SARS-CoV-2 infection were more prevalent in the older age group (12–18) compared with the younger age group (5–11). Some symptoms were more prevalent in children without a history of SARS-CoV-2 infection, including attention problems with school malfunctioning (225 (10.8%) vs 98 (8.5%), p=0.05), stress (190 (9.1%) vs 65 (5.7%), p<0.001), social problems (164 (7.8%) vs 32 (2.8%)) and weight changes (143 (6.8%) vs 43 (3.7%), p<0.001). CONCLUSION: This study suggests that the prevalence of long COVID symptoms in children with a history of SARS-CoV-2 infection might be higher and more prevalent in adolescents than in young children. Some of the symptoms, mainly somatic symptoms, were more prevalent in children without a history of SARS-CoV-2 infection, highlighting the impact of the pandemic itself rather than the infection.
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spelling pubmed-99446222023-02-22 Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study Adler, Limor Israel, Moran Yehoshua, Ilan Azuri, Joseph Hoffman, Robert Shahar, Arnon Mizrahi Reuveni, Miri Grossman, Zachi BMJ Open Paediatrics OBJECTIVES: To estimate the prevalence of long COVID symptoms in children with and without a history of SARS-CoV-2 infection and to evaluate factors associated with long COVID. DESIGN: A nationwide cross-sectional study. SETTING: Primary care. PARTICIPANTS: 3240 parents of children aged 5–18 with and without SARS-CoV-2 infection completed an online questionnaire (11.9% response rate); 1148 and 2092 with/without a history of infection, respectively. PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome was the prevalence of long COVID symptoms in children with/without a history of infection. Secondary outcomes were the factors associated with the presence of long COVID symptoms and with failure to return to baseline health status in children with a history of infection including gender, age, time from illness, symptomatic illness and vaccine status. RESULTS: Most long COVID symptoms were more prevalent in children with a history of SARS-CoV-2 infection: headaches (211 (18.4%) vs 114 (5.4%), p<0.001), weakness (173 (15.1%) vs 70 (3.3%), p<0.001), fatigue (141 (12.3%) vs 133 (6.4%), p<0.001) and abdominal pain (109 (9.5%) vs 79 (3.8%), p<0.001). Most long COVID symptoms in children with a history of SARS-CoV-2 infection were more prevalent in the older age group (12–18) compared with the younger age group (5–11). Some symptoms were more prevalent in children without a history of SARS-CoV-2 infection, including attention problems with school malfunctioning (225 (10.8%) vs 98 (8.5%), p=0.05), stress (190 (9.1%) vs 65 (5.7%), p<0.001), social problems (164 (7.8%) vs 32 (2.8%)) and weight changes (143 (6.8%) vs 43 (3.7%), p<0.001). CONCLUSION: This study suggests that the prevalence of long COVID symptoms in children with a history of SARS-CoV-2 infection might be higher and more prevalent in adolescents than in young children. Some of the symptoms, mainly somatic symptoms, were more prevalent in children without a history of SARS-CoV-2 infection, highlighting the impact of the pandemic itself rather than the infection. BMJ Publishing Group 2023-02-21 /pmc/articles/PMC9944622/ /pubmed/36810170 http://dx.doi.org/10.1136/bmjopen-2022-064155 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Paediatrics
Adler, Limor
Israel, Moran
Yehoshua, Ilan
Azuri, Joseph
Hoffman, Robert
Shahar, Arnon
Mizrahi Reuveni, Miri
Grossman, Zachi
Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study
title Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study
title_full Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study
title_fullStr Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study
title_full_unstemmed Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study
title_short Long COVID symptoms in Israeli children with and without a history of SARS-CoV-2 infection: a cross-sectional study
title_sort long covid symptoms in israeli children with and without a history of sars-cov-2 infection: a cross-sectional study
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944622/
https://www.ncbi.nlm.nih.gov/pubmed/36810170
http://dx.doi.org/10.1136/bmjopen-2022-064155
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