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Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation

BACKGROUND: The development of generic ophthalmic drug products is challenging due to the complexity of the ocular system, and a lack of sensitive testing to evaluate the interplay of physiology with ophthalmic formulations. While measurements of drug concentration at the site of action in humans ar...

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Detalles Bibliográficos
Autores principales:	Le Merdy, Maxime, AlQaraghuli, Farah, Tan, Ming-Liang, Walenga, Ross, Babiskin, Andrew, Zhao, Liang, Lukacova, Viera
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944674/ https://www.ncbi.nlm.nih.gov/pubmed/36151444 http://dx.doi.org/10.1007/s11095-022-03390-z

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