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In Silico Dosimetry Study of Tc99m-Tetrofosmin in Children Using a Novel PBPK Model in Humans Built from SPECT Imaging Data

PURPOSE: The aim of this work is to develop a Physiologically Based Pharmacokinetic model (PBPK) for the radiopharmaceutical Tc99m-Tetrofosmin in humans, from literature SPECT imaging data, to carry out in-silico dosimetry studies in children and extrapolate dosing. METHODS: A whole body PBPK model...

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Detalles Bibliográficos
Autores principales:	Kaikousidis, Christos, Dokoumetzidis, Aristides
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944701/ https://www.ncbi.nlm.nih.gov/pubmed/36261760 http://dx.doi.org/10.1007/s11095-022-03412-w

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