Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome

A proportion of patients with the acute coronary syndrome (ACS) will suffer progressive remodeling of the left ventricular (LV). The aim was to screen for important biomarkers from a large-scale protein profiling in 420 ACS patients and define biomarkers associated with reduced LV function early and...

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Autores principales: Christersson, Christina, Baron, Tomasz, Flachskampf, Frank, Lindhagen, Lars, Lindahl, Bertil, Siegbahn, Agneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944718/
https://www.ncbi.nlm.nih.gov/pubmed/35727504
http://dx.doi.org/10.1007/s12265-022-10285-2
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author Christersson, Christina
Baron, Tomasz
Flachskampf, Frank
Lindhagen, Lars
Lindahl, Bertil
Siegbahn, Agneta
author_facet Christersson, Christina
Baron, Tomasz
Flachskampf, Frank
Lindhagen, Lars
Lindahl, Bertil
Siegbahn, Agneta
author_sort Christersson, Christina
collection PubMed
description A proportion of patients with the acute coronary syndrome (ACS) will suffer progressive remodeling of the left ventricular (LV). The aim was to screen for important biomarkers from a large-scale protein profiling in 420 ACS patients and define biomarkers associated with reduced LV function early and 1 year after the ACS. Transferrin receptor protein 1 and NT-proBNP were associated with LV function early and after 1 year, whereas osteopontin and soluble ST2 were associated with LV function in the early phase and, tissue-type plasminogen activator after 1 year. Fatty-acid-binding protein and galectin 3 were related to worse GLS but not to LVEF 1 year after the ACS. Proteins involved in remodeling and iron transport in cardiomyocytes were related to worse LV function after ACS. Biomarkers for energy metabolism and fibrosis were exclusively related to worse LV function by GLS. Studies on the functions of these proteins might add knowledge to the biological processes involved in heart failure in long term after ACS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12265-022-10285-2.
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spelling pubmed-99447182023-02-23 Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome Christersson, Christina Baron, Tomasz Flachskampf, Frank Lindhagen, Lars Lindahl, Bertil Siegbahn, Agneta J Cardiovasc Transl Res Original Article A proportion of patients with the acute coronary syndrome (ACS) will suffer progressive remodeling of the left ventricular (LV). The aim was to screen for important biomarkers from a large-scale protein profiling in 420 ACS patients and define biomarkers associated with reduced LV function early and 1 year after the ACS. Transferrin receptor protein 1 and NT-proBNP were associated with LV function early and after 1 year, whereas osteopontin and soluble ST2 were associated with LV function in the early phase and, tissue-type plasminogen activator after 1 year. Fatty-acid-binding protein and galectin 3 were related to worse GLS but not to LVEF 1 year after the ACS. Proteins involved in remodeling and iron transport in cardiomyocytes were related to worse LV function after ACS. Biomarkers for energy metabolism and fibrosis were exclusively related to worse LV function by GLS. Studies on the functions of these proteins might add knowledge to the biological processes involved in heart failure in long term after ACS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12265-022-10285-2. Springer US 2022-06-21 2023 /pmc/articles/PMC9944718/ /pubmed/35727504 http://dx.doi.org/10.1007/s12265-022-10285-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Christersson, Christina
Baron, Tomasz
Flachskampf, Frank
Lindhagen, Lars
Lindahl, Bertil
Siegbahn, Agneta
Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
title Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
title_full Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
title_fullStr Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
title_full_unstemmed Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
title_short Screening for Biomarkers Associated with Left Ventricular Function During Follow-up After Acute Coronary Syndrome
title_sort screening for biomarkers associated with left ventricular function during follow-up after acute coronary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944718/
https://www.ncbi.nlm.nih.gov/pubmed/35727504
http://dx.doi.org/10.1007/s12265-022-10285-2
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