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Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve

Decreased ovarian reserve (DOR) is defined as a decrease in the quality and quantity of oocytes, which reduces ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of ooc...

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Autores principales: Lv, Zhexi, Lv, Zekai, Song, Linjiang, Zhang, Qinxiu, Zhu, Shaomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944763/
https://www.ncbi.nlm.nih.gov/pubmed/36845376
http://dx.doi.org/10.3389/fgene.2023.1056061
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author Lv, Zhexi
Lv, Zekai
Song, Linjiang
Zhang, Qinxiu
Zhu, Shaomi
author_facet Lv, Zhexi
Lv, Zekai
Song, Linjiang
Zhang, Qinxiu
Zhu, Shaomi
author_sort Lv, Zhexi
collection PubMed
description Decreased ovarian reserve (DOR) is defined as a decrease in the quality and quantity of oocytes, which reduces ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress, and the dysfunction of mitochondria. Although the mechanism of DOR is still unclear, recent studies have found that long non-coding RNA (lncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of granulosa cells in the ovary. LncRNAs participate in the occurrence of DOR by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. This review summarizes current research on lncRNAs associated with DOR and reveals the potential underlying mechanisms. The present study suggests that lncRNAs could be considered as prognostic markers and treatment targets for DOR.
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spelling pubmed-99447632023-02-23 Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve Lv, Zhexi Lv, Zekai Song, Linjiang Zhang, Qinxiu Zhu, Shaomi Front Genet Genetics Decreased ovarian reserve (DOR) is defined as a decrease in the quality and quantity of oocytes, which reduces ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress, and the dysfunction of mitochondria. Although the mechanism of DOR is still unclear, recent studies have found that long non-coding RNA (lncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of granulosa cells in the ovary. LncRNAs participate in the occurrence of DOR by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. This review summarizes current research on lncRNAs associated with DOR and reveals the potential underlying mechanisms. The present study suggests that lncRNAs could be considered as prognostic markers and treatment targets for DOR. Frontiers Media S.A. 2023-02-08 /pmc/articles/PMC9944763/ /pubmed/36845376 http://dx.doi.org/10.3389/fgene.2023.1056061 Text en Copyright © 2023 Lv, Lv, Song, Zhang and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Lv, Zhexi
Lv, Zekai
Song, Linjiang
Zhang, Qinxiu
Zhu, Shaomi
Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve
title Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve
title_full Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve
title_fullStr Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve
title_full_unstemmed Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve
title_short Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve
title_sort role of lncrnas in the pathogenic mechanism of human decreased ovarian reserve
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944763/
https://www.ncbi.nlm.nih.gov/pubmed/36845376
http://dx.doi.org/10.3389/fgene.2023.1056061
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