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SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy

In recent years, epigenetic mechanisms have been implicated in the development of multifactorial diseases including neurodegenerative disorders. In Parkinson’s disease (PD), as a synucleinopathy, most studies focused on DNA methylation of SNCA gene coding alpha-synuclein but obtained results were ra...

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Autores principales: Fedotova, Ekaterina Yu., Iakovenko, Elena V., Abramycheva, Natalia Yu., Illarioshkin, Sergey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944792/
https://www.ncbi.nlm.nih.gov/pubmed/36810559
http://dx.doi.org/10.3390/epigenomes7010005
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author Fedotova, Ekaterina Yu.
Iakovenko, Elena V.
Abramycheva, Natalia Yu.
Illarioshkin, Sergey N.
author_facet Fedotova, Ekaterina Yu.
Iakovenko, Elena V.
Abramycheva, Natalia Yu.
Illarioshkin, Sergey N.
author_sort Fedotova, Ekaterina Yu.
collection PubMed
description In recent years, epigenetic mechanisms have been implicated in the development of multifactorial diseases including neurodegenerative disorders. In Parkinson’s disease (PD), as a synucleinopathy, most studies focused on DNA methylation of SNCA gene coding alpha-synuclein but obtained results were rather contradictory. In another neurodegenerative synucleinopathy, multiple system atrophy (MSA), very few studies investigated the epigenetic regulation. This study included patients with PD (n = 82), patients with MSA (n = 24), and a control group (n = 50). In three groups, methylation levels of CpG and non-CpG sites in regulatory regions of the SNCA gene were analyzed. We revealed hypomethylation of CpG sites in the SNCA intron 1 in PD and hypermethylation of predominantly non-CpG sites in the SNCA promoter region in MSA. In PD patients, hypomethylation in the intron 1 was associated with earlier age at the disease onset. In MSA patients, hypermethylation in the promotor was associated with shorter disease duration (before examination). These results showed different patterns of the epigenetic regulation in two synucleinopathies—PD and MSA.
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spelling pubmed-99447922023-02-23 SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy Fedotova, Ekaterina Yu. Iakovenko, Elena V. Abramycheva, Natalia Yu. Illarioshkin, Sergey N. Epigenomes Article In recent years, epigenetic mechanisms have been implicated in the development of multifactorial diseases including neurodegenerative disorders. In Parkinson’s disease (PD), as a synucleinopathy, most studies focused on DNA methylation of SNCA gene coding alpha-synuclein but obtained results were rather contradictory. In another neurodegenerative synucleinopathy, multiple system atrophy (MSA), very few studies investigated the epigenetic regulation. This study included patients with PD (n = 82), patients with MSA (n = 24), and a control group (n = 50). In three groups, methylation levels of CpG and non-CpG sites in regulatory regions of the SNCA gene were analyzed. We revealed hypomethylation of CpG sites in the SNCA intron 1 in PD and hypermethylation of predominantly non-CpG sites in the SNCA promoter region in MSA. In PD patients, hypomethylation in the intron 1 was associated with earlier age at the disease onset. In MSA patients, hypermethylation in the promotor was associated with shorter disease duration (before examination). These results showed different patterns of the epigenetic regulation in two synucleinopathies—PD and MSA. MDPI 2023-02-06 /pmc/articles/PMC9944792/ /pubmed/36810559 http://dx.doi.org/10.3390/epigenomes7010005 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fedotova, Ekaterina Yu.
Iakovenko, Elena V.
Abramycheva, Natalia Yu.
Illarioshkin, Sergey N.
SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
title SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
title_full SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
title_fullStr SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
title_full_unstemmed SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
title_short SNCA Gene Methylation in Parkinson’s Disease and Multiple System Atrophy
title_sort snca gene methylation in parkinson’s disease and multiple system atrophy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944792/
https://www.ncbi.nlm.nih.gov/pubmed/36810559
http://dx.doi.org/10.3390/epigenomes7010005
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