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Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies

To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case–control study (1365 cases of pre-eclampsia and 1886 normotensive controls) was conducted. Pre-eclampsia was defined as blood pressure ≥ 140/90 mmHg and proteinuria ...

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Autores principales: Colmenares-Mejia, Claudia C., Quintero-Lesmes, Doris C., Bautista-Niño, Paula K., Guío, Elizabeth, Paez, Maria C., Beltrán, Mónica, Williams, David, Gray, Kathryn J., Casas, Juan P., Serrano, Norma C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944921/
https://www.ncbi.nlm.nih.gov/pubmed/36810371
http://dx.doi.org/10.1038/s41598-023-29651-4
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author Colmenares-Mejia, Claudia C.
Quintero-Lesmes, Doris C.
Bautista-Niño, Paula K.
Guío, Elizabeth
Paez, Maria C.
Beltrán, Mónica
Williams, David
Gray, Kathryn J.
Casas, Juan P.
Serrano, Norma C.
author_facet Colmenares-Mejia, Claudia C.
Quintero-Lesmes, Doris C.
Bautista-Niño, Paula K.
Guío, Elizabeth
Paez, Maria C.
Beltrán, Mónica
Williams, David
Gray, Kathryn J.
Casas, Juan P.
Serrano, Norma C.
author_sort Colmenares-Mejia, Claudia C.
collection PubMed
description To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case–control study (1365 cases of pre-eclampsia and 1886 normotensive controls) was conducted. Pre-eclampsia was defined as blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg/24 h. Sub-outcome analysis included early, intermediate, and late pre-eclampsia. Multivariable analysis for pre-eclampsia and its sub-outcomes was conducted using binary and multinomial logistic regression, respectively. Additionally, a systematic review and meta-analysis of cohort studies measuring uric acid levels < 20 weeks of gestation was performed to rule out reverse causation. There was a positive linear association between increasing uric acid levels and presence of pre-eclampsia. Adjusted odds ratio of pre-eclampsia was 1.21 (95%CI 1.11–1.33) for every one standard deviation increase in uric acid levels. No differences in the magnitude of association were observed between early and late pre-eclampsia. Three studies with uric acid measured < 20 weeks’ gestation were identified, with a pooled OR for pre-eclampsia of 1.46 (95%CI 1.22–1.75) for a top vs. bottom quartile comparison. Maternal uric acid levels are associated with risk of pre-eclampsia. Mendelian randomisation studies would be helpful to further explore the causal role of uric acid in pre-eclampsia.
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spelling pubmed-99449212023-02-23 Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies Colmenares-Mejia, Claudia C. Quintero-Lesmes, Doris C. Bautista-Niño, Paula K. Guío, Elizabeth Paez, Maria C. Beltrán, Mónica Williams, David Gray, Kathryn J. Casas, Juan P. Serrano, Norma C. Sci Rep Article To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case–control study (1365 cases of pre-eclampsia and 1886 normotensive controls) was conducted. Pre-eclampsia was defined as blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg/24 h. Sub-outcome analysis included early, intermediate, and late pre-eclampsia. Multivariable analysis for pre-eclampsia and its sub-outcomes was conducted using binary and multinomial logistic regression, respectively. Additionally, a systematic review and meta-analysis of cohort studies measuring uric acid levels < 20 weeks of gestation was performed to rule out reverse causation. There was a positive linear association between increasing uric acid levels and presence of pre-eclampsia. Adjusted odds ratio of pre-eclampsia was 1.21 (95%CI 1.11–1.33) for every one standard deviation increase in uric acid levels. No differences in the magnitude of association were observed between early and late pre-eclampsia. Three studies with uric acid measured < 20 weeks’ gestation were identified, with a pooled OR for pre-eclampsia of 1.46 (95%CI 1.22–1.75) for a top vs. bottom quartile comparison. Maternal uric acid levels are associated with risk of pre-eclampsia. Mendelian randomisation studies would be helpful to further explore the causal role of uric acid in pre-eclampsia. Nature Publishing Group UK 2023-02-21 /pmc/articles/PMC9944921/ /pubmed/36810371 http://dx.doi.org/10.1038/s41598-023-29651-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Colmenares-Mejia, Claudia C.
Quintero-Lesmes, Doris C.
Bautista-Niño, Paula K.
Guío, Elizabeth
Paez, Maria C.
Beltrán, Mónica
Williams, David
Gray, Kathryn J.
Casas, Juan P.
Serrano, Norma C.
Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
title Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
title_full Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
title_fullStr Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
title_full_unstemmed Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
title_short Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
title_sort uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944921/
https://www.ncbi.nlm.nih.gov/pubmed/36810371
http://dx.doi.org/10.1038/s41598-023-29651-4
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