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Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study

This study aimed to examine the efficacy and toxicity of reirradiation in patients with locally recurrent oral, pharyngeal, and laryngeal cancers. We conducted a retrospective, multi-institutional analysis of 129 patients with previously irradiated cancer. The most frequent primary sites were the na...

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Autores principales: Yamazaki, Hideya, Suzuki, Gen, Aibe, Norihiro, Shiomi, Hiroya, Oh, Ryoong-jin, Yoshida, Ken, Nakamura, Satoaki, Konishi, Koji, Ogita, Mikio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944926/
https://www.ncbi.nlm.nih.gov/pubmed/36810749
http://dx.doi.org/10.1038/s41598-023-29459-2
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author Yamazaki, Hideya
Suzuki, Gen
Aibe, Norihiro
Shiomi, Hiroya
Oh, Ryoong-jin
Yoshida, Ken
Nakamura, Satoaki
Konishi, Koji
Ogita, Mikio
author_facet Yamazaki, Hideya
Suzuki, Gen
Aibe, Norihiro
Shiomi, Hiroya
Oh, Ryoong-jin
Yoshida, Ken
Nakamura, Satoaki
Konishi, Koji
Ogita, Mikio
author_sort Yamazaki, Hideya
collection PubMed
description This study aimed to examine the efficacy and toxicity of reirradiation in patients with locally recurrent oral, pharyngeal, and laryngeal cancers. We conducted a retrospective, multi-institutional analysis of 129 patients with previously irradiated cancer. The most frequent primary sites were the nasopharynx (43.4%), oral cavity (24.8%), and oropharynx (18.6%). With a median follow-up duration of 10.6 months, the median overall survival was 14.4 months and the 2-year overall survival rate was 40.6%. For each primary site, the 2-year overall survival rates were 32.1%, 34.6%, 30%, 60.8%, and 5.7% for the hypopharynx, oral cavity, larynx, nasopharynx, and oropharynx, respectively. Prognostic factors for overall survival were primary site (nasopharynx versus other sites) and gross tumor volume (GTV) (≤ 25 cm(3) versus > 25 cm(3)). The 2-year local control rate was 41.2%. Twenty-four patients (18.6%) presented with grade ≥ 3 toxicities, including nine with hemorrhages that led to grade 5 toxicities in seven patients. All nine tumors that caused hemorrhage showed tumor encasement of the carotid ≥ 180 degrees and eight of nine tumors had larger GTV > 25 cm(3). Reirradiation is a feasible treatment option for small local recurrence of oral, pharyngeal, and laryngeal cancers, with the requirement of a strict eligibility assessment for large tumors with carotid encasement.
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spelling pubmed-99449262023-02-23 Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study Yamazaki, Hideya Suzuki, Gen Aibe, Norihiro Shiomi, Hiroya Oh, Ryoong-jin Yoshida, Ken Nakamura, Satoaki Konishi, Koji Ogita, Mikio Sci Rep Article This study aimed to examine the efficacy and toxicity of reirradiation in patients with locally recurrent oral, pharyngeal, and laryngeal cancers. We conducted a retrospective, multi-institutional analysis of 129 patients with previously irradiated cancer. The most frequent primary sites were the nasopharynx (43.4%), oral cavity (24.8%), and oropharynx (18.6%). With a median follow-up duration of 10.6 months, the median overall survival was 14.4 months and the 2-year overall survival rate was 40.6%. For each primary site, the 2-year overall survival rates were 32.1%, 34.6%, 30%, 60.8%, and 5.7% for the hypopharynx, oral cavity, larynx, nasopharynx, and oropharynx, respectively. Prognostic factors for overall survival were primary site (nasopharynx versus other sites) and gross tumor volume (GTV) (≤ 25 cm(3) versus > 25 cm(3)). The 2-year local control rate was 41.2%. Twenty-four patients (18.6%) presented with grade ≥ 3 toxicities, including nine with hemorrhages that led to grade 5 toxicities in seven patients. All nine tumors that caused hemorrhage showed tumor encasement of the carotid ≥ 180 degrees and eight of nine tumors had larger GTV > 25 cm(3). Reirradiation is a feasible treatment option for small local recurrence of oral, pharyngeal, and laryngeal cancers, with the requirement of a strict eligibility assessment for large tumors with carotid encasement. Nature Publishing Group UK 2023-02-21 /pmc/articles/PMC9944926/ /pubmed/36810749 http://dx.doi.org/10.1038/s41598-023-29459-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yamazaki, Hideya
Suzuki, Gen
Aibe, Norihiro
Shiomi, Hiroya
Oh, Ryoong-jin
Yoshida, Ken
Nakamura, Satoaki
Konishi, Koji
Ogita, Mikio
Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
title Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
title_full Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
title_fullStr Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
title_full_unstemmed Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
title_short Reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
title_sort reirradiation for local recurrence of oral, pharyngeal, and laryngeal cancers: a multi-institutional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9944926/
https://www.ncbi.nlm.nih.gov/pubmed/36810749
http://dx.doi.org/10.1038/s41598-023-29459-2
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